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【结 构 式】

【分子编号】55934

【品名】methyl 2-aminonicotinate

【CA登记号】14667-47-1

【 分 子 式 】C7H8N2O2

【 分 子 量 】152.1528

【元素组成】C 55.26% H 5.3% N 18.41% O 21.03%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(XX)

The intermediate amino alcohol (XVIII) was prepared by two ways. 2-Chloronicotinic acid (XIV) was converted to the corresponding acid chloride (XV) by treatment with oxalyl chloride, and then reacted with potassium tert-butoxide to afford the tert-butyl ester (XVI). Displacement of the chloride group of (XVI) with methanolic methylamine gave rise to the 2-(methylamino)nicotinic ester (XVII), which was then reduced to alcohol (XVIII) employing LiAlH4. Alternatively, 2-aminonicotinic acid (XIX) was esterified to (XX) by means of 2-chloro-1,3-dimethylimidazolinium chloride in MeOH. The amino group of (XX) was acylated with formic acetic anhydride to give formamide (XXI). Amino alcohol (XVIII) was then obtained by reduction of amido ester (XXI) in the presence of LiAlH4. Condensation of (XVIII) with 1-chloroethyl chloroformate produced the carbamate alcohol (XXII), which was subsequently esterified with N-Boc-sarcosine (XXIII) by means of EDC yielding (XXIV) (2). Quaternization of the triazole compound (XIII) with the chloroethyl carbamate (XXIV) in the presence of NaI furnished the corresponding triazolium salt, which was finally subjected to acidic Boc group cleavage to produce the title compound.

1 Ohwada, J.; Tsukazaki, M.; Hayase, T.; et al.; Design, synthesis and antifungal activity of a novel water soluble prodrug of antifungal triazole. Bioorg Med Chem Lett 2003, 13, 2, 191.
2 Hayase, T.; Tsukazaki, M.; Ohwada, J.; et al.; Development of novel water antifungal, RO0098557. 21st Symp Med Chem (Nov 28 2001, Kyoto) 2001, Abst 1P-06.
3 Ohwada, J.; et al.; RO0098557, a novel water soluble azole prodrug for parenteral and oral administration (I). Design, synthesis, physicochemical properties and bioconversion. 42nd Intersci Conf Antimicrob Agents Chemother (Sept 27 2002, San Diego) 2002, Abst F-820.
4 Shimma, N.; Fukuda, H.; Umeda, I.; Ohwada, J.; Sakaitani, M.; Oikawa, N.; Hayase, T.; Tsukazaki, M.; Mizuguchi, E. (F. Hoffmann-La Roche AG); N-Substd. carbamoyloxyalkyl-azolium derivs.. WO 0132652 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(XIII) 55929 4-{2-[(1R,2R)-2-(2,5-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-1,3-thiazol-4-yl}benzonitrile C22H17F2N5OS 详情 详情
(XIV) 28824 2-Chloropyridine-3-carboxylic acid; 2-Chloronicotinic acid 2942-59-8 C6H4ClNO2 详情 详情
(XV) 15224 2-chloronicotinoyl chloride 49609-84-9 C6H3Cl2NO 详情 详情
(XVI) 55930 tert-butyl 2-chloronicotinate C10H12ClNO2 详情 详情
(XVII) 55931 tert-butyl 2-(methylamino)nicotinate C11H16N2O2 详情 详情
(XVIII) 55932 [2-(methylamino)-3-pyridinyl]methanol C7H10N2O 详情 详情
(XIX) 55933 2-Aminonicotinic acid; 2-Aminopyridine-3-carboxylic acid 5345-47-1 C6H6N2O2 详情 详情
(XX) 55934 methyl 2-aminonicotinate 14667-47-1 C7H8N2O2 详情 详情
(XXI) 55935 methyl 2-(formylamino)nicotinate C8H8N2O3 详情 详情
(XXII) 55936 1-chloroethyl 3-(hydroxymethyl)-2-pyridinyl(methyl)carbamate C10H13ClN2O3 详情 详情
(XXIII) 55937 Boc-L-sarcosine; Boc-N-Methylglycine; Boc-sarcosine; N-tert-Butoxycarbonylsarcosine 13734-36-6 C8H15NO4 详情 详情
(XXIV) 55938 {2-[[(1-chloroethoxy)carbonyl](methyl)amino]-3-pyridinyl}methyl 2-[(tert-butoxycarbonyl)(methyl)amino]acetate C18H26ClN3O6 详情 详情

合成路线2

该中间体在本合成路线中的序号:(II)

Fischer esterification of 2-aminonicotinic acid (I) leads to methyl ester (II). Subsequent treatment of ester (II) with a methanolic solution of guanidine (III) provides (2-aminonicotinoyl)guanidine (IV). Finally, bromination of (IV) employing Br2/HBr affords the title compound.

1 Cragoe, E.J. Jr. (Merck & Co., Inc.); Certain aminopyridinecarbonyl guanidines. DE 1963317; FR 2026469; US 3586688 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 55933 2-Aminonicotinic acid; 2-Aminopyridine-3-carboxylic acid 5345-47-1 C6H6N2O2 详情 详情
(II) 55934 methyl 2-aminonicotinate 14667-47-1 C7H8N2O2 详情 详情
(III) 14790 Guanidine 113-00-8 CH5N3 详情 详情
(IV) 62994   C7H9N5O 详情 详情
Extended Information