|
【结 构 式】 
|
【药物名称】 【化学名称】N-(2-Amino-5-bromopyridin-3-ylcarbonyl)guanidine 【CA登记号】 【 分 子 式 】C7H8BrN5O 【 分 子 量 】258.07871 |
【开发单位】Therabel (Originator), University of Liege(Originator), University of Namur (Originator) 【药理作用】Acute Myocardial Infarction, Treatment of, Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS, Treatment of Disorders of the Coronary Arteries and Atherosclerosis, Na+/H+ Exchange (NHE) Inhibitors |
合成路线1
Fischer esterification of 2-aminonicotinic acid (I) leads to methyl ester (II). Subsequent treatment of ester (II) with a methanolic solution of guanidine (III) provides (2-aminonicotinoyl)guanidine (IV). Finally, bromination of (IV) employing Br2/HBr affords the title compound.
| 【1】 Cragoe, E.J. Jr. (Merck & Co., Inc.); Certain aminopyridinecarbonyl guanidines. DE 1963317; FR 2026469; US 3586688 . |
Extended Information