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【结 构 式】 
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【分子编号】58719 【品名】2-({[(tert-butoxycarbonyl)(hydroxy)amino]carbonyl}oxy)-2-methylpropane 【CA登记号】 |
【 分 子 式 】C10H19NO5 【 分 子 量 】233.2646 【元素组成】C 51.49% H 8.21% N 6% O 34.29% |
合成路线1
该中间体在本合成路线中的序号：(III)Sequential introduction of two tert-butoxycarbonyl groups into O-benzyl hydroxylamine (I) afforded the di-Boc-protected hydroxylamine (II). The O-benzyl group was then removed by hydrogenolysis over Pd/C yielding intermediate (III).
| 【1】 Koster, W.H.; Sundeen, J.E.; Straub, H.; Ermann, P.H.; Treuner, U. (Bristol-Myers Squibb Co.); Heteroaroyl derivs. of monocyclic beta-lactam antibiotics. EP 0484881; JP 1992283579 . |
合成路线2
该中间体在本合成路线中的序号：(III)Quinoxaline (VI) was prepared by condensation of phenylenediamine (IV) with tert-butyl 2,3-dioxobutyrate (V). Radical bromination of (VI) using N-bromosuccinimide and AIBN furnished the bromomethyl quinoxaline (VII) as the major brominated compound. This was condensed with N,N-di-Boc-hydroxylamine (III) to afford the protected O-alkyl hydroxylamine (VIII). Then, treatment of (VIII) with hot concentrated HCl gave rise to the fully deprotected quinoxaline (IX).
| 【1】 Koster, W.H.; Sundeen, J.E.; Straub, H.; Ermann, P.H.; Treuner, U. (Bristol-Myers Squibb Co.); Heteroaroyl derivs. of monocyclic beta-lactam antibiotics. EP 0484881; JP 1992283579 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 58719 | 2-({[(tert-butoxycarbonyl)(hydroxy)amino]carbonyl}oxy)-2-methylpropane | C10H19NO5 | 详情 | 详情 | |
| (IV) | 58720 | 2,2-dimethyl-1,3-benzodioxole-5,6-diamine; 6-amino-2,2-dimethyl-1,3-benzodioxol-5-ylamine | C9H12N2O2 | 详情 | 详情 | |
| (V) | 58721 | tert-butyl 2,3-dioxobutanoate | C8H12O4 | 详情 | 详情 | |
| (VI) | 58722 | tert-butyl 2,2,7-trimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate | C17H20N2O4 | 详情 | 详情 | |
| (VII) | 58723 | tert-butyl 7-(bromomethyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate | C17H19BrN2O4 | 详情 | 详情 | |
| (VIII) | 58724 | tert-butyl 7-({[bis(tert-butoxycarbonyl)amino]oxy}methyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate | C27H37N3O9 | 详情 | 详情 | |
| (IX) | 58725 | 3-[(aminooxy)methyl]-6,7-dihydroxy-2-quinoxalinecarboxylic acid | C10H9N3O5 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(III)In an alternative route to the title compound, dinitro derivative (XV) was converted into the benzofuroxan (XVI) by treatment with sodium azide in hot DMSO. Furazan ring opening by means of tert-butyl acetoacetate (XVII) under basic conditions generated the quinoxaline N,N'-dioxide (XVIII). The Pummerer-like rearrangement of the N-oxide (XVIII) in the presence of trifluoroacetic anhydride gave rise to the unstable trifluoroacetoxymethyl quinoxaline (XIX), which was further converted to bromide (XX) upon heating with LiBr in acetone. Alkylation of N,N-di-Boc-hydroxylamine (III) with bromide (XX) provided the protected O-alkyl hydroxylamine (XXI). Reduction of the remaining N-oxide group of (XXI) and simultaneous N-Boc groups cleavage by means of boron tribromide furnished quinoxaline (XXII). The fully deprotected quinoxaline (IX) was then obtained by acidic treatment of (XXII). Condensation of keto amide (XIII) with hydroxylamine (IX) in the presence of tetrabutylammonium bisulfate produced the oxime adduct (XXIII). Finally, the title compound was obtained by deformylation of (XXIII) under acidic conditions.
| 【1】 Koster, W.H.; Sundeen, J.E.; Straub, H.; Ermann, P.H.; Treuner, U. (Bristol-Myers Squibb Co.); Heteroaroyl derivs. of monocyclic beta-lactam antibiotics. EP 0484881; JP 1992283579 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (III) | 58719 | 2-({[(tert-butoxycarbonyl)(hydroxy)amino]carbonyl}oxy)-2-methylpropane | C10H19NO5 | 详情 | 详情 | |
| (IX) | 58725 | 3-[(aminooxy)methyl]-6,7-dihydroxy-2-quinoxalinecarboxylic acid | C10H9N3O5 | 详情 | 详情 | |
| (XIII) | 58728 | N,N,N-tributyl-1-butanaminium (2R,3S)-3-({2-[2-(formylamino)-1,3-thiazol-4-yl]-2-oxoacetyl}amino)-2-methyl-4-oxo-1-azetidinesulfonate | C26H45N5O7S2 | 详情 | 详情 | |
| (XV) | 58730 | 2,2-dimethyl-5,6-dinitro-1,3-benzodioxole | C9H8N2O6 | 详情 | 详情 | |
| (XVI) | 58731 | 6,6-dimethyl[1,3]dioxolo[4,5-f][2,1,3]benzoxadiazol-1-ium-1-olate | C9H8N2O4 | 详情 | 详情 | |
| (XVII) | 27907 | Acetoacetic acid tert-butyl ester;3-Oxo-butanoic acid 1,1-dimethylethyl estertert-butyl 3-oxobutanoate | 1694-31-1 | C8H14O3 | 详情 | 详情 |
| (XVIII) | 58732 | 6-(tert-butoxycarbonyl)-2,2,7-trimethyl[1,3]dioxolo[4,5-g]quinoxaline-5,8-diium-5,8-diolate | C17H20N2O6 | 详情 | 详情 | |
| (XIX) | 58733 | 6-(tert-butoxycarbonyl)-2,2-dimethyl-7-{[(2,2,2-trifluoroacetyl)oxy]methyl}[1,3]dioxolo[4,5-g]quinoxalin-5-ium-5-olate | C19H19F3N2O7 | 详情 | 详情 | |
| (XX) | 58734 | 7-(bromomethyl)-6-(tert-butoxycarbonyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxalin-5-ium-5-olate | C17H19BrN2O5 | 详情 | 详情 | |
| (XXI) | 58735 | 7-({[bis(tert-butoxycarbonyl)amino]oxy}methyl)-6-(tert-butoxycarbonyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxalin-5-ium-5-olate | C27H37N3O10 | 详情 | 详情 | |
| (XXII) | 58736 | tert-butyl 7-[(aminooxy)methyl]-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate | C17H21N3O5 | 详情 | 详情 | |
| (XXIII) | 58737 | di(N,N,N-tributyl-1-butanaminium) 3-({[((Z)-1-[2-(formylamino)-1,3-thiazol-4-yl]-2-{[(2R,3S)-2-methyl-4-oxo-1-sulfonatoazetidinyl]amino}-2-oxoethylidene)amino]oxy}methyl)-6,7-dihydroxy-2-quinoxalinecarboxylate | C52H87N9O11S2 | 详情 | 详情 |