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【结 构 式】

【分子编号】58721

【品名】tert-butyl 2,3-dioxobutanoate

【CA登记号】

【 分 子 式 】C8H12O4

【 分 子 量 】172.18088

【元素组成】C 55.81% H 7.02% O 37.17%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Quinoxaline (VI) was prepared by condensation of phenylenediamine (IV) with tert-butyl 2,3-dioxobutyrate (V). Radical bromination of (VI) using N-bromosuccinimide and AIBN furnished the bromomethyl quinoxaline (VII) as the major brominated compound. This was condensed with N,N-di-Boc-hydroxylamine (III) to afford the protected O-alkyl hydroxylamine (VIII). Then, treatment of (VIII) with hot concentrated HCl gave rise to the fully deprotected quinoxaline (IX).

1 Koster, W.H.; Sundeen, J.E.; Straub, H.; Ermann, P.H.; Treuner, U. (Bristol-Myers Squibb Co.); Heteroaroyl derivs. of monocyclic beta-lactam antibiotics. EP 0484881; JP 1992283579 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(III) 58719 2-({[(tert-butoxycarbonyl)(hydroxy)amino]carbonyl}oxy)-2-methylpropane C10H19NO5 详情 详情
(IV) 58720 2,2-dimethyl-1,3-benzodioxole-5,6-diamine; 6-amino-2,2-dimethyl-1,3-benzodioxol-5-ylamine C9H12N2O2 详情 详情
(V) 58721 tert-butyl 2,3-dioxobutanoate C8H12O4 详情 详情
(VI) 58722 tert-butyl 2,2,7-trimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate C17H20N2O4 详情 详情
(VII) 58723 tert-butyl 7-(bromomethyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate C17H19BrN2O4 详情 详情
(VIII) 58724 tert-butyl 7-({[bis(tert-butoxycarbonyl)amino]oxy}methyl)-2,2-dimethyl[1,3]dioxolo[4,5-g]quinoxaline-6-carboxylate C27H37N3O9 详情 详情
(IX) 58725 3-[(aminooxy)methyl]-6,7-dihydroxy-2-quinoxalinecarboxylic acid C10H9N3O5 详情 详情
Extended Information