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【结 构 式】 
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【分子编号】53969 【品名】2,2-Di-n-propylacetyl chloride; Di-n-propylacetyl chloride; Heptane-4-carbonyl chloride; 2-n-Propylpentanoyl chloride; 2-n-Propylvaleryl chloride 【CA登记号】2936-08-5 |
【 分 子 式 】C8H15ClO 【 分 子 量 】162.6592 【元素组成】C 59.07% H 9.29% Cl 21.8% O 9.84% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(II)The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.
| 【2】 Bialer, M.; Hadad, S.; Herzig, J.; Sterling, J.; Lerner, D.; Shirvan, M. (Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.); Derivs. of valproic and 2-valproenoic acid amides and use as anticonvulsants. EP 0659174; JP 1996504831; US 5585358; WO 9501956 . |
| 【1】 Hadad, S.; Bialer, M.; Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine. Pharm Res 1995, 12, 6, 905. |
合成路线2
该中间体在本合成路线中的序号：(II)The title compound is prepared by acylation of 5-amino-1,3,4-thiadiazole-2-sulfonamide (I) with valproyl chloride (II) in acetonitrile in the presence of triethylamine.
| 【1】 Abbate, F.; Scozzafava, A.; Supuran, C.T.; Masereel, B. ; Rolin, S.; Carbonic anhydrase inhibitors: Anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem 2002, 45, 2, 312. |
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