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【结 构 式】 
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【药物名称】Valrocemide, TVP-1901, TV-1901 【化学名称】N2-(2-Propylpentanoyl)glycinamide 【CA登记号】92262-58-3 【 分 子 式 】C10H20N2O2 【 分 子 量 】200.2831 |
【开发单位】Hebrew University (Originator), Yissum (Originator), Teva (Licensee), Acorda (Codevelopment) 【药理作用】ANALGESIC AND ANESTHETIC DRUGS, Analgesic Drugs, Antiepileptic Drugs, Bipolar Disorder, Treatment of, Mood Disorders, Treatment of, NEUROLOGIC DRUGS, Neuropathic Pain, Treatment of, PSYCHOPHARMACOLOGIC DRUGS |
合成路线1
The condensation of glycinamide (I) with 2-propylpentanoyl chloride (II) by means of TEA in dichloromethane/water gives the target N-acylated glycinamide.
| 【2】 Bialer, M.; Hadad, S.; Herzig, J.; Sterling, J.; Lerner, D.; Shirvan, M. (Teva Pharmaceutical Industries Ltd.; Yissum Research Development Co.); Derivs. of valproic and 2-valproenoic acid amides and use as anticonvulsants. EP 0659174; JP 1996504831; US 5585358; WO 9501956 . |
| 【1】 Hadad, S.; Bialer, M.; Pharmacokinetic analysis and antiepileptic activity of N-valproyl derivatives of GABA and glycine. Pharm Res 1995, 12, 6, 905. |
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