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【结 构 式】 
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【药物名称】 【化学名称】2-Propyl-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)pentanamide 【CA登记号】144462-39-5 【 分 子 式 】C10H18N4O3S2 【 分 子 量 】306.40796 |
【开发单位】Università degli Studi di Firenze (Originator), University of Namur (Originator) 【药理作用】Antiepileptic Drugs, NEUROLOGIC DRUGS, Carbonic Anhydrase Type I Inhibitors, Carbonic Anhydrase Type II Inhibitors, Carbonic Anhydrase Type IV Inhibitors |
合成路线1
The title compound is prepared by acylation of 5-amino-1,3,4-thiadiazole-2-sulfonamide (I) with valproyl chloride (II) in acetonitrile in the presence of triethylamine.
| 【1】 Abbate, F.; Scozzafava, A.; Supuran, C.T.; Masereel, B. ; Rolin, S.; Carbonic anhydrase inhibitors: Anticonvulsant sulfonamides incorporating valproyl and other lipophilic moieties. J Med Chem 2002, 45, 2, 312. |
Extended Information