tert-butyl 2-{(3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}-1-hydrazinecarboxylate -Drug Synthesis Database

【结构式】

【分子编号】53102

【品名】tert-butyl 2-{(3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}-1-hydrazinecarboxylate

【CA登记号】n/a

【分子式】C₁₇H₂₅N₅O₂

【分子量】331.418

【元素组成】C 61.61% H 7.6% N 21.13% O 9.66%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(XXVI)

In an alternative synthesis of hydrazine (XXIII), aldehyde (IX) was condensed with tert-butyl hydrazinecarboxylate (XXIV), producing hydrazone (XXV), which was further reduced to the hydrazinecarboxylate (XXVI) in the presence of NaBH(OAc)3. Acidic cleavage of the N-Boc group of (XXVI) provided hydrazine (XXIII).

参考文献中间体

合成目标

【1】 Kaneko, T.; McMillen, W.T.; McLaughlin, R.W.; Ripin, D.H.B.; Vanerplas, B.C. (Pfizer Inc.); Synthesis of carbamate ketolide antibiotics. EP 1088828; JP 2001151792 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(IX)	53087	3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butanal	n/a	C₁₂H₁₃N₃O	详情	详情
(XXIII)	53100	3-{1-[(1R)-3-hydrazino-1-methylpropyl]-1H-imidazol-4-yl}pyridine	n/a	C₁₂H₁₇N₅	详情	详情
(XXIV)	10893	tert-butyl 1-hydrazinecarboxylate; tert-butyl carbazate	870-46-2	C₅H₁₂N₂O₂	详情	详情
(XXV)	53101	tert-butyl 2-{(E,3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butylidene}-1-hydrazinecarboxylate	n/a	C₁₇H₂₃N₅O₂	详情	详情
(XXVI)	53102	tert-butyl 2-{(3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}-1-hydrazinecarboxylate	n/a	C₁₇H₂₅N₅O₂	详情	详情

Extended Information