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【结 构 式】 
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【分子编号】53101 【品名】tert-butyl 2-{(E,3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butylidene}-1-hydrazinecarboxylate 【CA登记号】n/a |
【 分 子 式 】C17H23N5O2 【 分 子 量 】329.40212 【元素组成】C 61.99% H 7.04% N 21.26% O 9.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XXV)In an alternative synthesis of hydrazine (XXIII), aldehyde (IX) was condensed with tert-butyl hydrazinecarboxylate (XXIV), producing hydrazone (XXV), which was further reduced to the hydrazinecarboxylate (XXVI) in the presence of NaBH(OAc)3. Acidic cleavage of the N-Boc group of (XXVI) provided hydrazine (XXIII).
| 【1】 Kaneko, T.; McMillen, W.T.; McLaughlin, R.W.; Ripin, D.H.B.; Vanerplas, B.C. (Pfizer Inc.); Synthesis of carbamate ketolide antibiotics. EP 1088828; JP 2001151792 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (IX) | 53087 | 3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butanal | n/a | C12H13N3O | 详情 | 详情 |
| (XXIII) | 53100 | 3-{1-[(1R)-3-hydrazino-1-methylpropyl]-1H-imidazol-4-yl}pyridine | n/a | C12H17N5 | 详情 | 详情 |
| (XXIV) | 10893 | tert-butyl 1-hydrazinecarboxylate; tert-butyl carbazate | 870-46-2 | C5H12N2O2 | 详情 | 详情 |
| (XXV) | 53101 | tert-butyl 2-{(E,3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butylidene}-1-hydrazinecarboxylate | n/a | C17H23N5O2 | 详情 | 详情 |
| (XXVI) | 53102 | tert-butyl 2-{(3R)-3-[4-(3-pyridinyl)-1H-imidazol-1-yl]butyl}-1-hydrazinecarboxylate | n/a | C17H25N5O2 | 详情 | 详情 |
Extended Information