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【结 构 式】 
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【分子编号】51624 【品名】(2R,3S,4R,5S)-2-(hydroxymethyl)-3,4,5-piperidinetriol 【CA登记号】 |
【 分 子 式 】C6H13NO4 【 分 子 量 】163.17356 【元素组成】C 44.17% H 8.03% N 8.58% O 39.22% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)The title compound was synthesized by reductive alkylation of deoxygalactojirimycin (I) with nonylaldehyde (II) in the presence of sodium cyanoborohydride.
| 【1】 Jacob, G.S.; Butters, T.D.; Fleet, G.W.J.; Carrouee, S.; Dwek, R.A.; Platt, F.M.; Zitzmann, N.; Picker, D.H.; Long chain N-alkyl cpds. and oxa-derivs. thereof. WO 0110429 . |
合成路线2
该中间体在本合成路线中的序号：(I)The title compound is prepared by reductive alkylation of deoxygalactonojirimycin (I) with butyraldehyde (II) under catalytic hydrogenation conditions in the presence of palladium black and sodium acetate buffer
| 【1】 Platt, F.M.; Neises, G.R.; Dwek, R.A.; Butters, T.D. (Pharmacia Corp.); Novel deoxygalactonojirimycin derivs.. EP 0698012; JP 1996510244; US 5399567; US 6291657; WO 9426714 . |
Extended Information