N-Nonyl-deoxygalactojirimycin, N-nonyl-DGJ, Alkovir, -Drug Synthesis Database

【结构式】

【药物名称】N-Nonyl-deoxygalactojirimycin, N-nonyl-DGJ, Alkovir

【化学名称】(2R,3S,4R,5S)-2-(Hydroxymethyl)-1-nonyl-3,4,5-piperidinetriol
　　　　　　1,5-Dideoxy-1,5-(nonylimino)-D-galactitol

【CA登记号】223771-83-3

【分子式】C₁₅H₃₁NO₄

【分子量】289.41862

【开发单位】Thomas Jefferson University (Originator), University of Oxford (Originator)

【药理作用】Anti-Hepatitis B Virus Drugs, Anti-Hepatitis Virus Drugs, ANTIINFECTIVE THERAPY, Antiviral Drugs, Iminosugars

合成路线1

The title compound was synthesized by reductive alkylation of deoxygalactojirimycin (I) with nonylaldehyde (II) in the presence of sodium cyanoborohydride.

参考文献中间体

【1】 Jacob, G.S.; Butters, T.D.; Fleet, G.W.J.; Carrouee, S.; Dwek, R.A.; Platt, F.M.; Zitzmann, N.; Picker, D.H.; Long chain N-alkyl cpds. and oxa-derivs. thereof. WO 0110429 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51624	(2R,3S,4R,5S)-2-(hydroxymethyl)-3,4,5-piperidinetriol		C₆H₁₃NO₄	详情	详情
(II)	38863	nonanal	124-19-6	C₉H₁₈O	详情	详情

Extended Information

Drug NewChemical Entity Original Patent(1)