N-Butylgalactonojirimycin, N-Butyldeoxygalactonojirimycin, CDP-923, OGT-923, -Drug Synthesis Database

【结构式】

【药物名称】N-Butylgalactonojirimycin, N-Butyldeoxygalactonojirimycin, CDP-923, OGT-923

【化学名称】1,5-(Butylimino)-1,5-dideoxy-D-galactitol
　　　　　　N-Butyldeoxygalactonojirimycin
　　　　　　(2R,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)-3,4,5-piperidinetriol

【CA登记号】141206-42-0

【分子式】C₁₀H₂₁NO₄

【分子量】219.28317

【开发单位】Celltech (Proprietary), Oxford GlycoSciences (Not Determined)

【药理作用】METABOLIC DRUGS, Therapy of Inborn Errors of Metabolism, Ceramide Glucosyltransferase Inhibitors, Iminosugars

合成路线1

The title compound is prepared by reductive alkylation of deoxygalactonojirimycin (I) with butyraldehyde (II) under catalytic hydrogenation conditions in the presence of palladium black and sodium acetate buffer

参考文献中间体

【1】 Platt, F.M.; Neises, G.R.; Dwek, R.A.; Butters, T.D. (Pharmacia Corp.); Novel deoxygalactonojirimycin derivs.. EP 0698012; JP 1996510244; US 5399567; US 6291657; WO 9426714 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	51624	(2R,3S,4R,5S)-2-(hydroxymethyl)-3,4,5-piperidinetriol		C₆H₁₃NO₄	详情	详情
(II)	23694	butyraldehyde	123-72-8	C₄H₈O	详情	详情

Extended Information