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【结 构 式】

【分子编号】50631

【品名】sodium 6-hydroxy-2-oxohexanoate

【CA登记号】

【 分 子 式 】C6H9NaO4

【 分 子 量 】168.124828

【元素组成】C 42.86% H 5.4% Na 13.67% O 38.07%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The hydrolysis of commercially available 5-(4-hydroxybutyl)hydantoin (I) gives racemic 6-hydroxynorleucine (rac)-(III), which is digested with T. variabilis D-amino acid oxidase to yield a mixture of the desired intermediate L-6-hydroxynorleucine (L)-(V) and the 6-hydroxy-2-oxohexanoic acid sodium salt (IV) that is separated by chromatography. The undesired 6-hydroxy-2-oxohexanoic acid sodium salt (IV) was converted to L-6-hydroxynorleucine (L)-(V) by reductive amination with glutamate dehydrogenase.

1 Patel, R.N.; Enzymatic synthesis of chiral intermediates for omapatrilat, an antihypertensive drug. Biomol Eng 2001, 17, 6, 167.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 50628 5-(4-hydroxybutyl)-2,4-imidazolidinedione C7H12N2O3 详情 详情
(II) 50629 N-(aminocarbonyl)-6-hydroxynorleucine C7H14N2O4 详情 详情
(III) 50630 6-hydroxynorleucine C6H13NO3 详情 详情
(IV) 50631 sodium 6-hydroxy-2-oxohexanoate C6H9NaO4 详情 详情
(V) 22502 (2S)-2-amino-6-hydroxyhexanoic acid 6033-32-5 C6H13NO3 详情 详情
Extended Information