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【结 构 式】 
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【分子编号】50629 【品名】N-(aminocarbonyl)-6-hydroxynorleucine 【CA登记号】 |
【 分 子 式 】C7H14N2O4 【 分 子 量 】190.19924 【元素组成】C 44.2% H 7.42% N 14.73% O 33.65% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(II)The hydrolysis of commercially available 5-(4-hydroxybutyl)hydantoin (I) gives racemic 6-hydroxynorleucine (rac)-(III), which is digested with T. variabilis D-amino acid oxidase to yield a mixture of the desired intermediate L-6-hydroxynorleucine (L)-(V) and the 6-hydroxy-2-oxohexanoic acid sodium salt (IV) that is separated by chromatography. The undesired 6-hydroxy-2-oxohexanoic acid sodium salt (IV) was converted to L-6-hydroxynorleucine (L)-(V) by reductive amination with glutamate dehydrogenase.
| 【1】 Patel, R.N.; Enzymatic synthesis of chiral intermediates for omapatrilat, an antihypertensive drug. Biomol Eng 2001, 17, 6, 167. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 50628 | 5-(4-hydroxybutyl)-2,4-imidazolidinedione | C7H12N2O3 | 详情 | 详情 | |
| (II) | 50629 | N-(aminocarbonyl)-6-hydroxynorleucine | C7H14N2O4 | 详情 | 详情 | |
| (III) | 50630 | 6-hydroxynorleucine | C6H13NO3 | 详情 | 详情 | |
| (IV) | 50631 | sodium 6-hydroxy-2-oxohexanoate | C6H9NaO4 | 详情 | 详情 | |
| (V) | 22502 | (2S)-2-amino-6-hydroxyhexanoic acid | 6033-32-5 | C6H13NO3 | 详情 | 详情 |
Extended Information