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【结 构 式】

【分子编号】50185

【品名】2-[4-(4-chlorobutoxy)phenyl]imidazo[1,2-a]pyridine; 4-chlorobutyl 4-imidazo[1,2-a]pyridin-2-ylphenyl ether

【CA登记号】

【 分 子 式 】C17H17ClN2O

【 分 子 量 】300.78756

【元素组成】C 67.88% H 5.7% Cl 11.79% N 9.31% O 5.32%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Coupling between phenol derivative (I) and 1-bromo-4-chlorobutane (II) by means of either Na2CO3/NaI or K2CO3 in refluxing 5-methyl-2-hexanone affords 4-chlorobutoxy derivative (III), which is then converted into the desired product by condensation with (2-methoxyphenyl)piperazine dihydrochloride (IV), either by means of Na2CO3/NaI or with K2CO3 in refluxing 5-methyl-2-hexanone.

1 Laszlovszky, I.; et al.; Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands. Pharmazie 2001, 56, 4, 287.
2 Laszlovszky, I.; Domány, G.; Ferenczy, G.; Szántay, C. Jr.; Thuroczyné Kálmán, E.; Lapis, E.; Trischler, F.; Hegedús, B.; Auth, F.; Csejtei, M.; Kárpáti, E.; Kiss, B.; Laszy, J.; Pellioniszné Paróczai, M.; Sarkadi, A.; Szabó, S. (Gedeon Richter Ltd.); 2-Methoxyphenylpiperazine derivs.. EP 0935599; US 6103724; WO 9818797 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 50184 4-imidazo[1,2-a]pyridin-2-ylphenol C13H10N2O 详情 详情
(II) 16141 1-bromo-4-chlorobutane 6940-78-9 C4H8BrCl 详情 详情
(III) 50185 2-[4-(4-chlorobutoxy)phenyl]imidazo[1,2-a]pyridine; 4-chlorobutyl 4-imidazo[1,2-a]pyridin-2-ylphenyl ether C17H17ClN2O 详情 详情
(IV) 11882 1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine 35386-24-4 C11H16N2O 详情 详情
Extended Information