4-imidazo[1,2-a]pyridin-2-ylphenol -Drug Synthesis Database

【结构式】

【分子编号】50184

【品名】4-imidazo[1,2-a]pyridin-2-ylphenol

【CA登记号】

【分子式】C₁₃H₁₀N₂O

【分子量】210.23528

【元素组成】C 74.27% H 4.79% N 13.32% O 7.61%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Coupling between phenol derivative (I) and 1-bromo-4-chlorobutane (II) by means of either Na2CO3/NaI or K2CO3 in refluxing 5-methyl-2-hexanone affords 4-chlorobutoxy derivative (III), which is then converted into the desired product by condensation with (2-methoxyphenyl)piperazine dihydrochloride (IV), either by means of Na2CO3/NaI or with K2CO3 in refluxing 5-methyl-2-hexanone.

参考文献中间体

合成目标

【1】 Laszlovszky, I.; et al.; Substituted phenoxyalkylpiperazines as dopamine D3 receptor ligands. Pharmazie 2001, 56, 4, 287.
【2】 Laszlovszky, I.; Domány, G.; Ferenczy, G.; Szántay, C. Jr.; Thuroczyné Kálmán, E.; Lapis, E.; Trischler, F.; Hegedús, B.; Auth, F.; Csejtei, M.; Kárpáti, E.; Kiss, B.; Laszy, J.; Pellioniszné Paróczai, M.; Sarkadi, A.; Szabó, S. (Gedeon Richter Ltd.); 2-Methoxyphenylpiperazine derivs.. EP 0935599; US 6103724; WO 9818797 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	50184	4-imidazo[1,2-a]pyridin-2-ylphenol		C₁₃H₁₀N₂O	详情	详情
(II)	16141	1-bromo-4-chlorobutane	6940-78-9	C₄H₈BrCl	详情	详情
(III)	50185	2-[4-(4-chlorobutoxy)phenyl]imidazo[1,2-a]pyridine; 4-chlorobutyl 4-imidazo[1,2-a]pyridin-2-ylphenyl ether		C₁₇H₁₇ClN₂O	详情	详情
(IV)	11882	1-(2-Methoxyphenyl)piperazine; Methyl 2-piperazinophenyl ether; 1-(2-Methoxyphenyl)-piperazine	35386-24-4	C₁₁H₁₆N₂O	详情	详情

Extended Information