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【结 构 式】 
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【分子编号】49524 【品名】7-chloro-2,3-dihydro-4(1H)-quinolinone 【CA登记号】 |
【 分 子 式 】C9H8ClNO 【 分 子 量 】181.62136 【元素组成】C 59.52% H 4.44% Cl 19.52% N 7.71% O 8.81% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(I)The condensation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one (I) with 2-methylbenzoyl chloride (II) by means of pyridine in dichloromethane gives the corresponding acyl quinolone (III), which is then treated with hydroxylamine-O-sulfonic acid (IV) and K2CO3 to yield the target oxime.
| 【1】 Uemura, A.; Mochida, E.; Haga, A.; Tokunaga, H.; Kato, K. (Mochida Pharmaceutical Co., Ltd.); 1-Acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivs.. AU 9058618; EP 0243982; JP 1988239270; JP 1993262737; US 4739368; WO 8706580 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 49524 | 7-chloro-2,3-dihydro-4(1H)-quinolinone | C9H8ClNO | 详情 | 详情 | |
| (II) | 14770 | 2-methylbenzoyl chloride; o-Toluoyl chloride | 933-88-0 | C8H7ClO | 详情 | 详情 |
| (III) | 49525 | 7-chloro-1-(2-methylbenzoyl)-2,3-dihydro-4(1H)-quinolinone | C17H14ClNO2 | 详情 | 详情 | |
| (IV) | 40596 | (aminooxy)(hydroxy)dioxo-lambda(6)-sulfane | 2950-43-8 | H3NO4S | 详情 | 详情 |
Extended Information