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【结 构 式】

【分子编号】40596

【品名】(aminooxy)(hydroxy)dioxo-lambda(6)-sulfane

【CA登记号】2950-43-8

【 分 子 式 】H3NO4S

【 分 子 量 】113.09416

【元素组成】H 2.67% N 12.39% O 56.59% S 28.35%

与该中间体有关的原料药合成路线共 2 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The condensation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one (I) with 2-methylbenzoyl chloride (II) by means of pyridine in dichloromethane gives the corresponding acyl quinolone (III), which is then treated with hydroxylamine-O-sulfonic acid (IV) and K2CO3 to yield the target oxime.

1 Uemura, A.; Mochida, E.; Haga, A.; Tokunaga, H.; Kato, K. (Mochida Pharmaceutical Co., Ltd.); 1-Acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivs.. AU 9058618; EP 0243982; JP 1988239270; JP 1993262737; US 4739368; WO 8706580 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 49524 7-chloro-2,3-dihydro-4(1H)-quinolinone C9H8ClNO 详情 详情
(II) 14770 2-methylbenzoyl chloride; o-Toluoyl chloride 933-88-0 C8H7ClO 详情 详情
(III) 49525 7-chloro-1-(2-methylbenzoyl)-2,3-dihydro-4(1H)-quinolinone C17H14ClNO2 详情 详情
(IV) 40596 (aminooxy)(hydroxy)dioxo-lambda(6)-sulfane 2950-43-8 H3NO4S 详情 详情

合成路线2

该中间体在本合成路线中的序号:

The protection of the OH group of 2-hydroxyacetonitrile (I) with TBDMS-Cl and imidazole in THF gives the silyl ether (II), which is treated with pentylmagnesium bromide (III) in ethyl ether yielding the protected 1-hydroxyoctan-3-one (IV), which is deprotected with HCl in methanol/water affording the corresponding hydroxyketone (V). Finally, this compound is treated with hydroxylamine-O-sulfonic acid in liquid ammonia.

1 Forman, S.A.; Miller, K.W.; Olsen, R.W.; Kloczewiak, M.A.; Addona, G.H.; Husain, S.S.; Cohen, J.B.; Pratt, M.B.; Synthesis and properties of 3-(2-hydroxyethyl)-3-N-pentyldiazirine, a photoactivable general anesthetic. J Med Chem 1999, 42, 17, 3300.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
40596 (aminooxy)(hydroxy)dioxo-lambda(6)-sulfane 2950-43-8 H3NO4S 详情 详情
(I) 14029 Ethylene cyanohydrin; ECN; 3-Hydroxypropanenitrile 109-78-4 C3H5NO 详情 详情
(II) 31870 3-[[tert-butyl(dimethyl)silyl]oxy]propanenitrile C9H19NOSi 详情 详情
(III) 31871 bromo(pentyl)magnesium 693-25-4 C5H11BrMg 详情 详情
(IV) 31872 1-[[tert-butyl(dimethyl)silyl]oxy]-3-octanone C14H30O2Si 详情 详情
(V) 31873 1-hydroxy-3-octanone C8H16O2 详情 详情
Extended Information