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【结 构 式】 
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【药物名称】M-17055 【化学名称】7-Chloro-1-(2-methylbenzoyl)-1,2,3,4-tetrahydroquinolin-4-one O-sulfooxime potassium salt 【CA登记号】114417-20-8 【 分 子 式 】C17H14ClKN2O5S 【 分 子 量 】432.93053 |
【开发单位】Mochida (Originator) 【药理作用】Diuretics, Loop Diuretics, RENAL-UROLOGIC DRUGS |
合成路线1
The condensation of 7-chloro-1,2,3,4-tetrahydroquinolin-4-one (I) with 2-methylbenzoyl chloride (II) by means of pyridine in dichloromethane gives the corresponding acyl quinolone (III), which is then treated with hydroxylamine-O-sulfonic acid (IV) and K2CO3 to yield the target oxime.
| 【1】 Uemura, A.; Mochida, E.; Haga, A.; Tokunaga, H.; Kato, K. (Mochida Pharmaceutical Co., Ltd.); 1-Acyl-2,3-dihydro-4(1H)-quinolinone-4-oxime derivs.. AU 9058618; EP 0243982; JP 1988239270; JP 1993262737; US 4739368; WO 8706580 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 49524 | 7-chloro-2,3-dihydro-4(1H)-quinolinone | C9H8ClNO | 详情 | 详情 | |
| (II) | 14770 | 2-methylbenzoyl chloride; o-Toluoyl chloride | 933-88-0 | C8H7ClO | 详情 | 详情 |
| (III) | 49525 | 7-chloro-1-(2-methylbenzoyl)-2,3-dihydro-4(1H)-quinolinone | C17H14ClNO2 | 详情 | 详情 | |
| (IV) | 40596 | (aminooxy)(hydroxy)dioxo-lambda(6)-sulfane | 2950-43-8 | H3NO4S | 详情 | 详情 |
Extended Information