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【结 构 式】

【分子编号】47631

【品名】ethyl 4,5-dimethoxy-2-[(4-nitrobenzoyl)amino]benzoate

【CA登记号】

【 分 子 式 】C18H18N2O7

【 分 子 量 】374.3502

【元素组成】C 57.75% H 4.85% N 7.48% O 29.92%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Treatment of substituted aminobenzoate (I) with 4-nitrobenzoyl chloride (II) affords amide (III), whose nitro group is converted into an amino group by hydrogenation over Pd/C, providing compound (IV). Finally, reaction of aniline (IV) with isocyanate (V) furnishes the target product.

1 Hayashi, H.; Goto, Y.; Isobe, Y.; Misawa, S.; Ogita, H.; Sekine, R.; Takaku, H.; Synthesis and structure-activity relationship of inhibitor on smooth muscle cell proliferation induced by PDGF. 19th Symp Med Chem (Nov 17 1999, Tokyo) 1999, Abst 1P-03.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 47630 ethyl 2-amino-4,5-dimethoxybenzoate C11H15NO4 详情 详情
(II) 18941 p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride 122-04-3 C7H4ClNO3 详情 详情
(III) 47631 ethyl 4,5-dimethoxy-2-[(4-nitrobenzoyl)amino]benzoate C18H18N2O7 详情 详情
(IV) 47632 ethyl 2-[(4-aminobenzoyl)amino]-4,5-dimethoxybenzoate C18H20N2O5 详情 详情
(V) 47633 4-isocyanatoaniline; 4-isocyanatophenylamine C7H6N2O 详情 详情
Extended Information