【结 构 式】 |
【药物名称】 【化学名称】2-[4-[3-(4-Aminophenyl)ureido]benzamido]-4,5-dimethoxybenzoic acid ethyl ester 【CA登记号】 【 分 子 式 】C25H26N4O6 【 分 子 量 】478.50917 |
【开发单位】Japan Energy (Originator) 【药理作用】CARDIOVASCULAR DRUGS, Restenosis Treatment of, Treatment of Disorders of the Coronary Arteries and Atherosclerosis |
合成路线1
Treatment of substituted aminobenzoate (I) with 4-nitrobenzoyl chloride (II) affords amide (III), whose nitro group is converted into an amino group by hydrogenation over Pd/C, providing compound (IV). Finally, reaction of aniline (IV) with isocyanate (V) furnishes the target product.
【1】 Hayashi, H.; Goto, Y.; Isobe, Y.; Misawa, S.; Ogita, H.; Sekine, R.; Takaku, H.; Synthesis and structure-activity relationship of inhibitor on smooth muscle cell proliferation induced by PDGF. 19th Symp Med Chem (Nov 17 1999, Tokyo) 1999, Abst 1P-03. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 47630 | ethyl 2-amino-4,5-dimethoxybenzoate | C11H15NO4 | 详情 | 详情 | |
(II) | 18941 | p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride | 122-04-3 | C7H4ClNO3 | 详情 | 详情 |
(III) | 47631 | ethyl 4,5-dimethoxy-2-[(4-nitrobenzoyl)amino]benzoate | C18H18N2O7 | 详情 | 详情 | |
(IV) | 47632 | ethyl 2-[(4-aminobenzoyl)amino]-4,5-dimethoxybenzoate | C18H20N2O5 | 详情 | 详情 | |
(V) | 47633 | 4-isocyanatoaniline; 4-isocyanatophenylamine | C7H6N2O | 详情 | 详情 |
Extended Information