N-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]amine; N-[3-(trifluoromethyl)phenyl]-4-piperidinamine -Drug Synthesis Database

【结构式】

【分子编号】47584

【品名】N-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]amine; N-[3-(trifluoromethyl)phenyl]-4-piperidinamine

【CA登记号】

【分子式】C₁₂H₁₅F₃N₂

【分子量】244.2597896

【元素组成】C 59.01% H 6.19% F 23.33% N 11.47%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Treatment of 3-chloro-6-methylpyridazine (I) with thionyl chloride followed by reaction with imino derivative (II) in CH2Cl2 provides thiadiazolyl pyridazine derivative (III), which is then condensed with amine (IV) in the presence of Na2CO3 in DMF.

参考文献中间体

合成目标

【1】 Stokbroekx, R.A.; Van der Aa, M.J.M.; Willems, M.; Meerpoel, L.; Luyckx, M.G.M.; Tuman, R.W. (Janssen Pharmaceutica NV); Angiogenesis inhibiting pyridazinamines. EP 0876366; JP 2000503014; US 5985878; WO 9726258 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	13495	3-Chloro-6-methylpyridazine	1121-79-5	C₅H₅ClN₂	详情	详情
(II)	15369	Iminoformamide; Methanimidamide	463-52-5	CH₄N₂	详情	详情
(III)	47583	3-chloro-6-(1,2,4-thiadiazol-5-yl)pyridazine		C₆H₃ClN₄S	详情	详情
(IV)	47584	N-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]amine; N-[3-(trifluoromethyl)phenyl]-4-piperidinamine		C₁₂H₁₅F₃N₂	详情	详情

Extended Information