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【结 构 式】 
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【分子编号】47583 【品名】3-chloro-6-(1,2,4-thiadiazol-5-yl)pyridazine 【CA登记号】 |
【 分 子 式 】C6H3ClN4S 【 分 子 量 】198.63548 【元素组成】C 36.28% H 1.52% Cl 17.85% N 28.21% S 16.14% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Treatment of 3-chloro-6-methylpyridazine (I) with thionyl chloride followed by reaction with imino derivative (II) in CH2Cl2 provides thiadiazolyl pyridazine derivative (III), which is then condensed with amine (IV) in the presence of Na2CO3 in DMF.
| 【1】 Stokbroekx, R.A.; Van der Aa, M.J.M.; Willems, M.; Meerpoel, L.; Luyckx, M.G.M.; Tuman, R.W. (Janssen Pharmaceutica NV); Angiogenesis inhibiting pyridazinamines. EP 0876366; JP 2000503014; US 5985878; WO 9726258 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13495 | 3-Chloro-6-methylpyridazine | 1121-79-5 | C5H5ClN2 | 详情 | 详情 |
| (II) | 15369 | Iminoformamide; Methanimidamide | 463-52-5 | CH4N2 | 详情 | 详情 |
| (III) | 47583 | 3-chloro-6-(1,2,4-thiadiazol-5-yl)pyridazine | C6H3ClN4S | 详情 | 详情 | |
| (IV) | 47584 | N-(4-piperidinyl)-N-[3-(trifluoromethyl)phenyl]amine; N-[3-(trifluoromethyl)phenyl]-4-piperidinamine | C12H15F3N2 | 详情 | 详情 |
Extended Information