N-(5-chloro-2-hydroxyphenyl)urea -Drug Synthesis Database

【结构式】

【分子编号】47832

【品名】N-(5-chloro-2-hydroxyphenyl)urea

【CA登记号】

【分子式】C₇H₇ClN₂O₂

【分子量】186.59756

【元素组成】C 45.06% H 3.78% Cl 19% N 15.01% O 17.15%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(II)

Condensation of chloroacetyl derivative (I) with phenolic compound (II) by means of K2CO3 in DMF affords the desired compound.

【1】 Monahan, S.D.; Xu, W.; Morissey, M.M.; Bauman, J.G.; Ng, H.P.; Hesselgesser, J.E.; Liang, M.; Zheng, W.; Islam, I.; May, K.B.; Ghannam, A.F.; Buckman, B.O.; Horuk, R.; Wei, G.P. (Schering AG); Piperazine derivs. and their use as anti-inflammatory agents. US 6207665; WO 9856771 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	47831	2-chloro-1-[(2R)-4-(4-fluorobenzyl)-2-methylpiperazinyl]-1-ethanone		C₁₄H₁₈ClFN₂O	详情	详情
(II)	47832	N-(5-chloro-2-hydroxyphenyl)urea		C₇H₇ClN₂O₂	详情	详情

Extended Information