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【结 构 式】 
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【分子编号】47831 【品名】2-chloro-1-[(2R)-4-(4-fluorobenzyl)-2-methylpiperazinyl]-1-ethanone 【CA登记号】 |
【 分 子 式 】C14H18ClFN2O 【 分 子 量 】284.7609032 【元素组成】C 59.05% H 6.37% Cl 12.45% F 6.67% N 9.84% O 5.62% |
与该中间体有关的原料药合成路线共 2 条
合成路线1
该中间体在本合成路线中的序号：(I)Condensation of chloroacetyl derivative (I) with phenolic compound (II) by means of K2CO3 in DMF affords the desired compound.
| 【1】 Monahan, S.D.; Xu, W.; Morissey, M.M.; Bauman, J.G.; Ng, H.P.; Hesselgesser, J.E.; Liang, M.; Zheng, W.; Islam, I.; May, K.B.; Ghannam, A.F.; Buckman, B.O.; Horuk, R.; Wei, G.P. (Schering AG); Piperazine derivs. and their use as anti-inflammatory agents. US 6207665; WO 9856771 . |
合成路线2
该中间体在本合成路线中的序号：(II)In a further method, 1-(4-fluorobenzyl)-3-methylpiperazine (I) is acylated by chloroacetyl chloride to provide the chloroacetamide (II). Subsequent chloride displacement with 4-chlorophenol (III) leads to the target chlorophenoxy acetamide.
| 【1】 Monahan, S.D.; Xu, W.; Morissey, M.M.; Bauman, J.G.; Ng, H.P.; Hesselgesser, J.E.; Liang, M.; Zheng, W.; Islam, I.; May, K.B.; Ghannam, A.F.; Buckman, B.O.; Horuk, R.; Wei, G.P. (Schering AG); Piperazine derivs. and their use as anti-inflammatory agents. US 6207665; WO 9856771 . |
Extended Information