|
【结 构 式】 
|
【药物名称】ZK-811752, BX-471 【化学名称】N-[5-Chloro-2-[2-[4-(4-fluorobenzyl)-2(R)-methylpiperazin-1-yl]-2-oxoethoxy]phenyl]urea hydrochloride 【CA登记号】288262-96-4, 217645-70-0 (free base) 【 分 子 式 】C21H25Cl2FN4O3 【 分 子 量 】471.3628 |
【开发单位】Berlex (Originator) 【药理作用】Immunologic Neuromuscular Disorders, Treatment of, IMMUNOMODULATING AGENTS, Multiple Sclerosis, Agents for, NEUROLOGIC DRUGS, Treatment of Transplant Rejection, Chemokine CCR1 Antagonists |
合成路线1
Condensation of chloroacetyl derivative (I) with phenolic compound (II) by means of K2CO3 in DMF affords the desired compound.
| 【1】 Monahan, S.D.; Xu, W.; Morissey, M.M.; Bauman, J.G.; Ng, H.P.; Hesselgesser, J.E.; Liang, M.; Zheng, W.; Islam, I.; May, K.B.; Ghannam, A.F.; Buckman, B.O.; Horuk, R.; Wei, G.P. (Schering AG); Piperazine derivs. and their use as anti-inflammatory agents. US 6207665; WO 9856771 . |
Extended Information