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【结 构 式】

【分子编号】45967

【品名】2-(2-aminophenoxy)-5-methoxybenzoic acid

【CA登记号】

【 分 子 式 】C14H13NO4

【 分 子 量 】259.26156

【元素组成】C 64.86% H 5.05% N 5.4% O 24.68%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(V)

Condensation of 2-chloronitrobenzene (I) with 2-hydroxy-4-methoxybenzaldehyde (II) by means of Cu/KOH in refluxing DMF provides derivative (III), which is then oxidized with KMnO4 in pyridine/H2O to afford carboxylic acid (IV). Reduction of the nitro moiety of (IV) by hydrogenation over Pd/C yields amine (V), which is then cyclized at high temperatures to furnish the dibenzo[b,f][1,4]oxazepinone intermediate (VI) (1). O-Demethylation of (VI) by treatment with AlCl3 in ethylmercaptan (EtSH) gives hydroxy derivative (VII), which then reacts with triflic anhydride in CH2Cl2 in the presence of Et3N to provide compound (VIII). Treatment of (VIII) with POCl3 in refluxing toluene in the presence of N,N-dimethylaniline yields chloro derivative (IX), which is finally condensed with N-methylpiperazine (X) in refluxing toluene to give the desired product.

1 Wikstrom, H.; Liao, Y.; Venhuis, B.J.; Rodenhuis, N.; Timmerman, W.; New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: Chemistry and pharmacological evaluation. J Med Chem 1999, 42, 12, 2235.
2 De Boer, P.; Liao, Y.; Wikstrom, H.; New sulfone ester analogues of iso-clozapine and related structures: Atypical neuroleptics. WO 9629316 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 15248 1-chloro-2-nitrobenzene 88-73-3 C6H4ClNO2 详情 详情
(II) 29301 2-hydroxy-5-methoxybenzaldehyde 672-13-9 C8H8O3 详情 详情
(III) 45965 5-methoxy-2-(2-nitrophenoxy)benzaldehyde C14H11NO5 详情 详情
(IV) 45966 5-methoxy-2-(2-nitrophenoxy)benzoic acid C14H11NO6 详情 详情
(V) 45967 2-(2-aminophenoxy)-5-methoxybenzoic acid C14H13NO4 详情 详情
(VI) 45968 2-methoxydibenzo[b,f][1,4]oxazepin-11(10H)-one C14H11NO3 详情 详情
(VII) 45969 2-hydroxydibenzo[b,f][1,4]oxazepin-11(10H)-one C13H9NO3 详情 详情
(VIII) 45970 11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl trifluoromethanesulfonate C14H8F3NO5S 详情 详情
(IX) 45971 11-chlorodibenzo[b,f][1,4]oxazepin-2-yl trifluoromethanesulfonate C14H7ClF3NO4S 详情 详情
(X) 10061 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine 109-01-3 C5H12N2 详情 详情
Extended Information