【结 构 式】 |
【分子编号】29301 【品名】2-hydroxy-5-methoxybenzaldehyde 【CA登记号】672-13-9 |
【 分 子 式 】C8H8O3 【 分 子 量 】152.14972 【元素组成】C 63.15% H 5.3% O 31.55% |
合成路线1
该中间体在本合成路线中的序号:(I)Bromination of 2-hydroxy-5-methoxybenzaldehyde (I) in acetic acid / sodium acetate mixture gives bromoaldehyde (II). Condensation to the benzofuranylpyridine (IV) is achieved by heating a solution of (II) and 4-(chloromethyl)pyridine hydrochloride (III) in polyethylene glycol-400 in the presence of potassium carbonate. Quaternization of (IV) with dimethylsulfate in dichloromethane affords (V), which upon reduction with sodium borohydride gives intermediate (VI). Reduction of (VI) with platinum on charcoal in methanol/HBr solution yields the N-methylpiperidine (VII). Degradation of the N-methyl group with ethylchloroformate in toluene affords the carbamate (VIII). Final treatment of (VIII) with potassium hydroxide in n-butanol yields the free base of brofaremine, which is converted to its hydrochloride salt by treatment with hydrochloric acid in methanol.
【1】 Schenker, K.; Bernasconi, R. (Novartis AG); Tetrahydropyridine and piperidine derivatives and processes for the preparation thereof. DE 2653147; ES 453582; FR 2332754; GB 1565055; JP 52065277 . |
【2】 Waldmeier, P.C.; Schilling, W.; Brofaremine Hydrochloride. Drugs Fut 1985, 10, 5, 371. |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 29301 | 2-hydroxy-5-methoxybenzaldehyde | 672-13-9 | C8H8O3 | 详情 | 详情 |
(II) | 29302 | 3-bromo-2-hydroxy-5-methoxybenzaldehyde | C8H7BrO3 | 详情 | 详情 | |
(III) | 10844 | 4-(Chloromethyl)pyridine | 10445-91-7 | C6H6ClN | 详情 | 详情 |
(IV) | 29303 | 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)pyridine | C14H10BrNO2 | 详情 | 详情 | |
(V) | 29304 | 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)-1-methylpyridinium (sulfonatooxy)methane | C16H16BrNO6S | 详情 | 详情 | |
(VI) | 29305 | 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)-1-methyl-1,2,3,6-tetrahydropyridine | C15H16BrNO2 | 详情 | 详情 | |
(VII) | 29306 | 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)-1-methylpiperidine | C15H18BrNO2 | 详情 | 详情 | |
(VIII) | 29307 | ethyl 4-(7-bromo-5-methoxy-1-benzofuran-2-yl)-1-piperidinecarboxylate | C17H20BrNO4 | 详情 | 详情 | |
(IX) | 11229 | 1-[(Chlorocarbonyl)oxy]ethane;ethyl carbonochloridate; Carbonchloridic acid ethyl ester;Ethyl chloroformate;Ethyl chlorocarbonate | 541-41-3 | C3H5ClO2 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号:(II)Condensation of 2-chloronitrobenzene (I) with 2-hydroxy-4-methoxybenzaldehyde (II) by means of Cu/KOH in refluxing DMF provides derivative (III), which is then oxidized with KMnO4 in pyridine/H2O to afford carboxylic acid (IV). Reduction of the nitro moiety of (IV) by hydrogenation over Pd/C yields amine (V), which is then cyclized at high temperatures to furnish the dibenzo[b,f][1,4]oxazepinone intermediate (VI) (1). O-Demethylation of (VI) by treatment with AlCl3 in ethylmercaptan (EtSH) gives hydroxy derivative (VII), which then reacts with triflic anhydride in CH2Cl2 in the presence of Et3N to provide compound (VIII). Treatment of (VIII) with POCl3 in refluxing toluene in the presence of N,N-dimethylaniline yields chloro derivative (IX), which is finally condensed with N-methylpiperazine (X) in refluxing toluene to give the desired product.
【1】 Wikstrom, H.; Liao, Y.; Venhuis, B.J.; Rodenhuis, N.; Timmerman, W.; New (sulfonyloxy)piperazinyldibenzazepines as potential atypical antipsychotics: Chemistry and pharmacological evaluation. J Med Chem 1999, 42, 12, 2235. |
【2】 De Boer, P.; Liao, Y.; Wikstrom, H.; New sulfone ester analogues of iso-clozapine and related structures: Atypical neuroleptics. WO 9629316 . |
中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
---|---|---|---|---|---|---|
(I) | 15248 | 1-chloro-2-nitrobenzene | 88-73-3 | C6H4ClNO2 | 详情 | 详情 |
(II) | 29301 | 2-hydroxy-5-methoxybenzaldehyde | 672-13-9 | C8H8O3 | 详情 | 详情 |
(III) | 45965 | 5-methoxy-2-(2-nitrophenoxy)benzaldehyde | C14H11NO5 | 详情 | 详情 | |
(IV) | 45966 | 5-methoxy-2-(2-nitrophenoxy)benzoic acid | C14H11NO6 | 详情 | 详情 | |
(V) | 45967 | 2-(2-aminophenoxy)-5-methoxybenzoic acid | C14H13NO4 | 详情 | 详情 | |
(VI) | 45968 | 2-methoxydibenzo[b,f][1,4]oxazepin-11(10H)-one | C14H11NO3 | 详情 | 详情 | |
(VII) | 45969 | 2-hydroxydibenzo[b,f][1,4]oxazepin-11(10H)-one | C13H9NO3 | 详情 | 详情 | |
(VIII) | 45970 | 11-oxo-10,11-dihydrodibenzo[b,f][1,4]oxazepin-2-yl trifluoromethanesulfonate | C14H8F3NO5S | 详情 | 详情 | |
(IX) | 45971 | 11-chlorodibenzo[b,f][1,4]oxazepin-2-yl trifluoromethanesulfonate | C14H7ClF3NO4S | 详情 | 详情 | |
(X) | 10061 | 1-Methylpiperazine; 1-Methyl piperazine; N-Methylpiperazine | 109-01-3 | C5H12N2 | 详情 | 详情 |