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【结 构 式】

【分子编号】45771

【品名】1-(2,5-dichlorophenyl)piperazine

【CA登记号】1013-27-0

【 分 子 式 】C10H12Cl2N2

【 分 子 量 】231.12416

【元素组成】C 51.97% H 5.23% Cl 30.68% N 12.12%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III). This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.

1 Testa, R.; Leonardi, A.; Motta, G.; Barlocco, D. (Recordati Industria Chimica e Farmaceutica SpA); Cyclic amides and imides having selective antagonist activity at alpha-1D adrenergic receptor. WO 0105765 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 28020 8-azaspiro[4.5]decane-7,9-dione 1075-89-4 C9H13NO2 详情 详情
(II) 33274 1-chloro-2-propanol; 1-chloroisopropanol 127-00-4 C3H7ClO 详情 详情
(III) 45770 8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione C12H18ClNO2 详情 详情
(IV) 45771 1-(2,5-dichlorophenyl)piperazine 1013-27-0 C10H12Cl2N2 详情 详情
Extended Information