8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione -Drug Synthesis Database

【结构式】

【分子编号】45770

【品名】8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione

【CA登记号】

【分子式】C₁₂H₁₈ClNO₂

【分子量】243.73316

【元素组成】C 59.14% H 7.44% Cl 14.55% N 5.75% O 13.13%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(III)

Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III). This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.

参考文献中间体

合成目标

【1】 Testa, R.; Leonardi, A.; Motta, G.; Barlocco, D. (Recordati Industria Chimica e Farmaceutica SpA); Cyclic amides and imides having selective antagonist activity at alpha-1D adrenergic receptor. WO 0105765 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	28020	8-azaspiro[4.5]decane-7,9-dione	1075-89-4	C₉H₁₃NO₂	详情	详情
(II)	33274	1-chloro-2-propanol; 1-chloroisopropanol	127-00-4	C₃H₇ClO	详情	详情
(III)	45770	8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione		C₁₂H₁₈ClNO₂	详情	详情
(IV)	45771	1-(2,5-dichlorophenyl)piperazine	1013-27-0	C₁₀H₁₂Cl₂N₂	详情	详情

Extended Information