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【结 构 式】 
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【分子编号】45770 【品名】8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione 【CA登记号】 |
【 分 子 式 】C12H18ClNO2 【 分 子 量 】243.73316 【元素组成】C 59.14% H 7.44% Cl 14.55% N 5.75% O 13.13% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Mitsunobu coupling of 3,3-tetramethyleneglutarimide (I) with 1-chloro-2-propanol (II) afforded the N-(2-chloro-1-methylethyl) glutarimide (III). This was then condensed with N-(2,5-dichlorophenyl)piperazine (IV) in the presence of Et3N at 180 C to furnish the title compound.
| 【1】 Testa, R.; Leonardi, A.; Motta, G.; Barlocco, D. (Recordati Industria Chimica e Farmaceutica SpA); Cyclic amides and imides having selective antagonist activity at alpha-1D adrenergic receptor. WO 0105765 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 28020 | 8-azaspiro[4.5]decane-7,9-dione | 1075-89-4 | C9H13NO2 | 详情 | 详情 |
| (II) | 33274 | 1-chloro-2-propanol; 1-chloroisopropanol | 127-00-4 | C3H7ClO | 详情 | 详情 |
| (III) | 45770 | 8-(2-chloro-1-methylethyl)-8-azaspiro[4.5]decane-7,9-dione | C12H18ClNO2 | 详情 | 详情 | |
| (IV) | 45771 | 1-(2,5-dichlorophenyl)piperazine | 1013-27-0 | C10H12Cl2N2 | 详情 | 详情 |
Extended Information