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【结 构 式】

【分子编号】40947

【品名】[4-(4-nitrobenzoyl)-1-piperazinyl](4-nitrophenyl)methanone

【CA登记号】

【 分 子 式 】C18H16N4O6

【 分 子 量 】384.3484

【元素组成】C 56.25% H 4.2% N 14.58% O 24.98%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(IV)

The acylation of piperazine (II) with 4-nitrobenzoyl chloride (I) afforded a mixture of monoacylated (III) and diacylated (IV) products, which were separated by chromatography. Subsequent alkylation of monosubstituted piperazine (III) with 4-nitrophenethyl bromide (V) in the presence of K2CO3 and NaI yielded the title compound.

1 Kanojia, R.M.; Kauffman, J.; Salata, J.J.; Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines. Bioorg Med Chem Lett 2000, 10, 24, 2819.
2 Kanojia, R.M.; et al.; Synthesis and selective class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 204.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 18941 p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride 122-04-3 C7H4ClNO3 详情 详情
(II) 10355 Diethylenediamine; Piperazine 110-85-0 C4H10N2 详情 详情
(III) 20011 (4-nitrophenyl)(1-piperazinyl)methanone C11H13N3O3 详情 详情
(IV) 40947 [4-(4-nitrobenzoyl)-1-piperazinyl](4-nitrophenyl)methanone C18H16N4O6 详情 详情
(V) 19191 1-(2-bromoethyl)-4-nitrobenzene 5339-26-4 C8H8BrNO2 详情 详情
Extended Information