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【结 构 式】 
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【药物名称】RWJ-28810 【化学名称】[4-[2-(4-Nitrophenyl)ethyl]piperazin-1-yl](4-nitrophenyl)methanone 【CA登记号】 【 分 子 式 】C19H20N4O5 【 分 子 量 】384.39505 |
【开发单位】R.W. Johnson (Originator) 【药理作用】Antiarrhythmic Drugs, CARDIOVASCULAR DRUGS |
合成路线1
The acylation of piperazine (II) with 4-nitrobenzoyl chloride (I) afforded a mixture of monoacylated (III) and diacylated (IV) products, which were separated by chromatography. Subsequent alkylation of monosubstituted piperazine (III) with 4-nitrophenethyl bromide (V) in the presence of K2CO3 and NaI yielded the title compound.
| 【1】 Kanojia, R.M.; Kauffman, J.; Salata, J.J.; Synthesis and class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines. Bioorg Med Chem Lett 2000, 10, 24, 2819. |
| 【2】 Kanojia, R.M.; et al.; Synthesis and selective class III type antiarrhythmic activity of 4-aroyl (and aryl)-1-aralkylpiperazines. 219th ACS Natl Meet (March 26 2000, San Francisco) 2000, Abst MEDI 204. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 18941 | p-nitrobenzoyl chloride; 4-nitrobenzoyl chloride | 122-04-3 | C7H4ClNO3 | 详情 | 详情 |
| (II) | 10355 | Diethylenediamine; Piperazine | 110-85-0 | C4H10N2 | 详情 | 详情 |
| (III) | 20011 | (4-nitrophenyl)(1-piperazinyl)methanone | C11H13N3O3 | 详情 | 详情 | |
| (IV) | 40947 | [4-(4-nitrobenzoyl)-1-piperazinyl](4-nitrophenyl)methanone | C18H16N4O6 | 详情 | 详情 | |
| (V) | 19191 | 1-(2-bromoethyl)-4-nitrobenzene | 5339-26-4 | C8H8BrNO2 | 详情 | 详情 |
Extended Information