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【结 构 式】 
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【分子编号】40526 【品名】 【CA登记号】 |
【 分 子 式 】C48H50N2O8 【 分 子 量 】782.93368 【元素组成】C 73.64% H 6.44% N 3.58% O 16.35% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(V)Cyclocondensation of a mixture of benzylamine (I), ethyl propiolate (II) and benzaldehyde (III) in hot AcOH furnished dihydropyridine (IV). Photodimerization of this compound in a MeOH-THF solution gave rise to the cage dimer (V). Finally, reduction of the ester groups of (V) by means of LiAlH4 at low temperature produced the title tetraol compound.
| 【1】 Wiese, M.; Billich, A.; Hilgeroth, A.; Synthesis and biological evaluation of the first N-alkyl cage dimeric 4-aryl-1,4-dihydropyridines as novel nonpeptidic HIV-1 protease inhibitors. J Med Chem 1999, 42, 22, 4729. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 15147 | Benzylamine; Phenylmethanamine | 100-46-9 | C7H9N | 详情 | 详情 |
| (II) | 35333 | ethyl propiolate | 623-47-2 | C5H6O2 | 详情 | 详情 |
| (III) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (IV) | 40525 | diethyl 1-benzyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate | C24H25NO4 | 详情 | 详情 | |
| (V) | 40526 | C48H50N2O8 | 详情 | 详情 |
Extended Information