diethyl 1-benzyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate -Drug Synthesis Database

【结构式】

【分子编号】40525

【品名】diethyl 1-benzyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate

【CA登记号】

【分子式】C₂₄H₂₅NO₄

【分子量】391.46684

【元素组成】C 73.64% H 6.44% N 3.58% O 16.35%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(IV)

Cyclocondensation of a mixture of benzylamine (I), ethyl propiolate (II) and benzaldehyde (III) in hot AcOH furnished dihydropyridine (IV). Photodimerization of this compound in a MeOH-THF solution gave rise to the cage dimer (V). Finally, reduction of the ester groups of (V) by means of LiAlH4 at low temperature produced the title tetraol compound.

参考文献中间体

合成目标

【1】 Wiese, M.; Billich, A.; Hilgeroth, A.; Synthesis and biological evaluation of the first N-alkyl cage dimeric 4-aryl-1,4-dihydropyridines as novel nonpeptidic HIV-1 protease inhibitors. J Med Chem 1999, 42, 22, 4729.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	15147	Benzylamine; Phenylmethanamine	100-46-9	C₇H₉N	详情	详情
(II)	35333	ethyl propiolate	623-47-2	C₅H₆O₂	详情	详情
(III)	10498	Benzaldehyde;Benzoic aldehyde;Phenylmethanal	100-52-7	C₇H₆O	详情	详情
(IV)	40525	diethyl 1-benzyl-4-phenyl-1,4-dihydro-3,5-pyridinedicarboxylate		C₂₄H₂₅NO₄	详情	详情
(V)	40526			C₄₈H₅₀N₂O₈	详情	详情

Extended Information