4-(4-methoxyphenyl)-2-butanamine; 3-(4-methoxyphenyl)-1-methylpropylamine -Drug Synthesis Database

【结构式】

【分子编号】40181

【品名】4-(4-methoxyphenyl)-2-butanamine; 3-(4-methoxyphenyl)-1-methylpropylamine

【CA登记号】

【分子式】C₁₁H₁₇NO

【分子量】179.26212

【元素组成】C 73.7% H 9.56% N 7.81% O 8.93%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(X)

The reaction of 4-(4-methoxyphenyl)-2-butylamine (X) with 3,4-dimethoxyphenylacetic acid (XI) at 200 C gives 2-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl-1-methyl-n-propyl)acetamide (XII), which is then reduced with borane in THF to yield 3,4-dimethoxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine (I), which by demethylation with HBr in refluxing acetic acid.

参考文献中间体

合成目标

【1】 Castaner, J.; Thorpe, P.; Dobutamine. Drugs Fut 1977, 2, 9, 579.
【2】 Tuttle, R.R.; Mills, J. (Eli Lilly and Company); Dopamine derivatives. DE 2317710; ES 413639; FR 2182947; GB 1392674; JP 49007237 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	40177	N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)-2-butanamine; N-(3,4-dimethoxyphenethyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]amine		C₂₁H₂₉NO₃	详情	详情
(X)	40181	4-(4-methoxyphenyl)-2-butanamine; 3-(4-methoxyphenyl)-1-methylpropylamine		C₁₁H₁₇NO	详情	详情
(XI)	40182	3-(3,4-dimethoxyphenyl)propionic acid	2107-70-2	C₁₁H₁₄O₄	详情	详情
(XII)	40183	3-(3,4-dimethoxyphenyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]propanamide		C₂₂H₂₉NO₄	详情	详情

Extended Information