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【结 构 式】 
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【分子编号】40177 【品名】N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)-2-butanamine; N-(3,4-dimethoxyphenethyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]amine 【CA登记号】 |
【 分 子 式 】C21H29NO3 【 分 子 量 】343.4662 【元素组成】C 73.44% H 8.51% N 4.08% O 13.97% |
合成路线1
该中间体在本合成路线中的序号：(I)The reduction of 4-(p-methoxyphenyl)-3-buten-2-one (II) with hydrogen over Raney-Ni in ethyl acetate gives the corresponding butanone (III), which is then condensed with homoveratrylamine (IV) in the same solvent to give the imine (V). This product, without isolation, is reduced again with hydrogen over Pd/C to yield 3,4-dimethoxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine (I), which by demethylation with HBr in refluxing acetic acid.
| 【1】 Castaner, J.; Thorpe, P.; Dobutamine. Drugs Fut 1977, 2, 9, 579. |
| 【2】 Tuttle, R.R.; Mills, J. (Eli Lilly and Company); Dopamine derivatives. DE 2317710; ES 413639; FR 2182947; GB 1392674; JP 49007237 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40177 | N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)-2-butanamine; N-(3,4-dimethoxyphenethyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]amine | C21H29NO3 | 详情 | 详情 | |
| (II) | 40174 | (E)-4-(4-methoxyphenyl)-3-buten-2-one | 943-88-4 | C11H12O2 | 详情 | 详情 |
| (III) | 40175 | 4-(4-methoxyphenyl)-2-butanone | 104-20-1 | C11H14O2 | 详情 | 详情 |
| (IV) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
| (V) | 40176 | N-(3,4-dimethoxyphenethyl)-N-[(E)-3-(4-methoxyphenyl)-1-methylpropylidene]amine; 2-(3,4-dimethoxyphenyl)-N-[(E)-3-(4-methoxyphenyl)-1-methylpropylidene]-1-ethanamine | C21H27NO3 | 详情 | 详情 |
合成路线2
该中间体在本合成路线中的序号：(I)The Friedel-Crafts reaction of anisole (VI) with crotonyl chloride (VII) by means of AlCl3 in carbon disulfide gives p-methoxyphenyl propenyl ketone (VIII), which is then condensed with homoveratrylamine (IV) in toluene yielding 3-(3,4-dimethoxyphenylethylamino)-1-(4-methoxyphenyl)butan-1-one (IX). Finally, this ketone is reduced with hydrogen over Pd/C in ethanol to yield 3,4-dimethoxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine (I), which by demethylation with HBr in refluxing acetic acid.
| 【1】 Castaner, J.; Thorpe, P.; Dobutamine. Drugs Fut 1977, 2, 9, 579. |
| 【2】 Tuttle, R.R.; Mills, J. (Eli Lilly and Company); Dopamine derivatives. DE 2317710; ES 413639; FR 2182947; GB 1392674; JP 49007237 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40177 | N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)-2-butanamine; N-(3,4-dimethoxyphenethyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]amine | C21H29NO3 | 详情 | 详情 | |
| (IV) | 10098 | 2-(3,4-Dimethoxyphenyl)-1-ethanamine; 3,4-Dimethoxyphenethylamine; 2-(3,4-Dimethoxyphenyl)ethylamine | 120-20-7 | C10H15NO2 | 详情 | 详情 |
| (VI) | 23767 | Methoxybenzene; Methyl phenyl ether; Anisole | 100-66-3 | C7H8O | 详情 | 详情 |
| (VII) | 40178 | (E)-2-Butenoyl chloride; (E)-Crotonyl chloride | 625-35-4 | C4H5ClO | 详情 | 详情 |
| (VIII) | 40179 | (E)-1-(4-methoxyphenyl)-2-buten-1-one | C11H12O2 | 详情 | 详情 | |
| (IX) | 40180 | 3-[(3,4-dimethoxyphenethyl)amino]-1-(4-methoxyphenyl)-1-butanone | C21H27NO4 | 详情 | 详情 |
合成路线3
该中间体在本合成路线中的序号：(I)The reaction of 4-(4-methoxyphenyl)-2-butylamine (X) with 3,4-dimethoxyphenylacetic acid (XI) at 200 C gives 2-(3,4-dimethoxyphenyl)-N-(4-methoxyphenyl-1-methyl-n-propyl)acetamide (XII), which is then reduced with borane in THF to yield 3,4-dimethoxy-N-[3-(4-hydroxyphenyl)-1-methylpropyl]-beta-phenylethylamine (I), which by demethylation with HBr in refluxing acetic acid.
| 【1】 Castaner, J.; Thorpe, P.; Dobutamine. Drugs Fut 1977, 2, 9, 579. |
| 【2】 Tuttle, R.R.; Mills, J. (Eli Lilly and Company); Dopamine derivatives. DE 2317710; ES 413639; FR 2182947; GB 1392674; JP 49007237 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 40177 | N-(3,4-dimethoxyphenethyl)-4-(4-methoxyphenyl)-2-butanamine; N-(3,4-dimethoxyphenethyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]amine | C21H29NO3 | 详情 | 详情 | |
| (X) | 40181 | 4-(4-methoxyphenyl)-2-butanamine; 3-(4-methoxyphenyl)-1-methylpropylamine | C11H17NO | 详情 | 详情 | |
| (XI) | 40182 | 3-(3,4-dimethoxyphenyl)propionic acid | 2107-70-2 | C11H14O4 | 详情 | 详情 |
| (XII) | 40183 | 3-(3,4-dimethoxyphenyl)-N-[3-(4-methoxyphenyl)-1-methylpropyl]propanamide | C22H29NO4 | 详情 | 详情 |