|
【结 构 式】 
|
【分子编号】39293 【品名】9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-ylamine; 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-amine 【CA登记号】 |
【 分 子 式 】C24H42ClN5O2Si2 【 分 子 量 】524.25368 【元素组成】C 54.99% H 8.07% Cl 6.76% N 13.36% O 6.1% Si 10.71% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)Coupling of known allylic alcohol (I) with 2-amino-6-chloropurine (II) under Mitsunobu conditions furnished nucleoside (III). Subsequent desilylation and chloride hydrolysis by means of aqueous trifluoroacetic acid yielded the title compound.
| 【1】 Froeyen, M.; Hendrix, C.; De Clercq, E.; Herdewijn, P.; Snoeck, R.; Wang, J.; Andrei, G.; The cyclohexene ring system as a furanose mimic: Synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. J Med Chem 2000, 43, 4, 736. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39292 | (1R,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-ol | C19H40O3Si2 | 详情 | 详情 | |
| (II) | 11644 | 6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine | 10310-21-1 | C5H4ClN5 | 详情 | 详情 |
| (III) | 39293 | 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-ylamine; 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-amine | C24H42ClN5O2Si2 | 详情 | 详情 |
Extended Information