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【结 构 式】 
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【药物名称】 【化学名称】9-[5(S)-Hydroxy-4(R)-(hydroxymethyl)-2-cyclohexen-1(S)-yl]guanine 【CA登记号】 【 分 子 式 】C12H15N5O3 【 分 子 量 】277.28505 |
【开发单位】Rega Institute for Medical Research (Originator) 【药理作用】Anti-Cytomegalovirus Drugs, Anti-Herpes Virus Drugs, ANTIINFECTIVE THERAPY, Anti-Varicella Zoster Virus Drugs, Antiviral Drugs |
合成路线1
Coupling of known allylic alcohol (I) with 2-amino-6-chloropurine (II) under Mitsunobu conditions furnished nucleoside (III). Subsequent desilylation and chloride hydrolysis by means of aqueous trifluoroacetic acid yielded the title compound.
| 【1】 Froeyen, M.; Hendrix, C.; De Clercq, E.; Herdewijn, P.; Snoeck, R.; Wang, J.; Andrei, G.; The cyclohexene ring system as a furanose mimic: Synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. J Med Chem 2000, 43, 4, 736. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 39292 | (1R,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-ol | C19H40O3Si2 | 详情 | 详情 | |
| (II) | 11644 | 6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine | 10310-21-1 | C5H4ClN5 | 详情 | 详情 |
| (III) | 39293 | 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-ylamine; 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-amine | C24H42ClN5O2Si2 | 详情 | 详情 |
Extended Information