(1R,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-ol -Drug Synthesis Database

【结构式】

【分子编号】39292

【品名】(1R,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-ol

【CA登记号】

【分子式】C₁₉H₄₀O₃Si₂

【分子量】372.6958

【元素组成】C 61.23% H 10.82% O 12.88% Si 15.07%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(I)

Coupling of known allylic alcohol (I) with 2-amino-6-chloropurine (II) under Mitsunobu conditions furnished nucleoside (III). Subsequent desilylation and chloride hydrolysis by means of aqueous trifluoroacetic acid yielded the title compound.

参考文献中间体

合成目标

【1】 Froeyen, M.; Hendrix, C.; De Clercq, E.; Herdewijn, P.; Snoeck, R.; Wang, J.; Andrei, G.; The cyclohexene ring system as a furanose mimic: Synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. J Med Chem 2000, 43, 4, 736.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	39292	(1R,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-ol		C₁₉H₄₀O₃Si₂	详情	详情
(II)	11644	6-Chloro-9H-purin-2-amine; 6-Chloro-9H-purin-2-ylamine; 2-Amino-6-chloropurine	10310-21-1	C₅H₄ClN₅	详情	详情
(III)	39293	9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-ylamine; 9-[(1S,4R,5S)-5-[[tert-butyl(dimethyl)silyl]oxy]-4-([[tert-butyl(dimethyl)silyl]oxy]methyl)-2-cyclohexen-1-yl]-6-chloro-9H-purin-2-amine		C₂₄H₄₂ClN₅O₂Si₂	详情	详情

Extended Information