5-chloro-2-methoxyphenylamine; 5-chloro-2-methoxyaniline -Drug Synthesis Database

【结构式】

【分子编号】37092

【品名】5-chloro-2-methoxyphenylamine; 5-chloro-2-methoxyaniline

【CA登记号】95-03-4

【分子式】C₇H₈ClNO

【分子量】157.59936

【元素组成】C 53.35% H 5.12% Cl 22.5% N 8.89% O 10.15%

与该中间体有关的原料药合成路线共 2 条

合成路线1 合成路线2

合成路线1

该中间体在本合成路线中的序号：(I)

The diazotation of 2-amino-4-chloroanisole (I) with NaNO2 and HCl in water gives the corresponding diazonium salt (II), which is then condensed with imidazole (III) by means of NaOH and sodium acetate in water.

参考文献中间体

合成目标

【1】 Niimura, I.; Maeda, S.; Okazaki, H. (Mochida Pharmaceutical Co., Ltd.); Azo cpds.. DE 3028928 .
【2】 Mochida, E.; Suzuki, Y.; Onishi, H.; Kosuzume, H. (Mochida Pharmaceutical Co., Ltd.); Compsns. containing azo cpds. and use thereof for therapeutic treatment. GB 2057874 .
【3】 Blancafort, P.; Serradell, M.N.; Grau, M.; Castaner, J.; M-6434. Drugs Fut 1982, 7, 12, 887.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37092	5-chloro-2-methoxyphenylamine; 5-chloro-2-methoxyaniline	95-03-4	C₇H₈ClNO	详情	详情
(II)	37093			C₇H₇Cl₂NO	详情	详情
(III)	10255	Imidazole; 1H-Imidazole	288-32-4	C₃H₄N₂	详情	详情

合成路线2

该中间体在本合成路线中的序号：(I)

Acylation of 5-chloroanisidine (I) with 3,5-bis(trifluoromethyl)benzoyl chloride (II) affords benzamide (III). Treatment of amide (III) with PCl5, followed by reaction of the intermediate iminoyl chloride with hydrazine in THF generates the amidrazone (IV). Cyclization of (IV) with carbonyl diimidazole leads to triazolone (V). Finally, methyl ether cleavage in (V) employing pyridine hydrochloride at 225 C provides the target phenol compound.

参考文献中间体

合成目标

【1】 Romine, J.L.; et al.; 4,5-Diphenyltriazol-3-ones: Openers of large-conductance Ca2+-activated potassium (maxi-K) channels. J Med Chem 2002, 45, 14, 2942.
【2】 Meanwell, N.A.; Starrett, J.E. Jr.; Hewawasam, P.; Romine, J.L.; Martin, S.W.; Gribkoff, V.K. (Bristol-Myers Squibb Co.); Diphenyl oxadiazolones as potassium channel modulators. JP 2000516925; US 5869509; WO 9804135 .

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(I)	37092	5-chloro-2-methoxyphenylamine; 5-chloro-2-methoxyaniline	95-03-4	C₇H₈ClNO	详情	详情
(II)	18290	3,5-Bis(trifluoromethyl)benzoyl chloride	785-56-8	C₉H₃ClF₆O	详情	详情
(III)	58514	N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzamide		C₁₆H₁₀ClF₆NO₂	详情	详情
(IV)	58515	N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzenecarbohydrazonamide		C₁₆H₁₂ClF₆N₃O	详情	详情
(V)	58516	5-[3,5-bis(trifluoromethyl)phenyl]-4-(5-chloro-2-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one		C₁₇H₁₀ClF₆N₃O₂	详情	详情

Extended Information