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【结 构 式】 
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【药物名称】 【化学名称】5-[3,5-Bis(trifluoromethyl)phenyl]-4-(5-chloro-2-hydroxyphenyl)-3,4-dihydro-2H-1,2,4-triazol-3-one 【CA登记号】202821-61-2 【 分 子 式 】C16H8ClF6N3O2 【 分 子 量 】423.70446 |
【开发单位】Bristol-Myers Squibb (Originator) 【药理作用】Cerebrovascular Diseases, Treatment of, Ischemic Stroke, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, Large Conductance BK(Ca) Channel Activators |
合成路线1
Acylation of 5-chloroanisidine (I) with 3,5-bis(trifluoromethyl)benzoyl chloride (II) affords benzamide (III). Treatment of amide (III) with PCl5, followed by reaction of the intermediate iminoyl chloride with hydrazine in THF generates the amidrazone (IV). Cyclization of (IV) with carbonyl diimidazole leads to triazolone (V). Finally, methyl ether cleavage in (V) employing pyridine hydrochloride at 225 C provides the target phenol compound.
| 【1】 Romine, J.L.; et al.; 4,5-Diphenyltriazol-3-ones: Openers of large-conductance Ca2+-activated potassium (maxi-K) channels. J Med Chem 2002, 45, 14, 2942. |
| 【2】 Meanwell, N.A.; Starrett, J.E. Jr.; Hewawasam, P.; Romine, J.L.; Martin, S.W.; Gribkoff, V.K. (Bristol-Myers Squibb Co.); Diphenyl oxadiazolones as potassium channel modulators. JP 2000516925; US 5869509; WO 9804135 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 37092 | 5-chloro-2-methoxyphenylamine; 5-chloro-2-methoxyaniline | 95-03-4 | C7H8ClNO | 详情 | 详情 |
| (II) | 18290 | 3,5-Bis(trifluoromethyl)benzoyl chloride | 785-56-8 | C9H3ClF6O | 详情 | 详情 |
| (III) | 58514 | N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzamide | C16H10ClF6NO2 | 详情 | 详情 | |
| (IV) | 58515 | N-(5-chloro-2-methoxyphenyl)-3,5-bis(trifluoromethyl)benzenecarbohydrazonamide | C16H12ClF6N3O | 详情 | 详情 | |
| (V) | 58516 | 5-[3,5-bis(trifluoromethyl)phenyl]-4-(5-chloro-2-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one | C17H10ClF6N3O2 | 详情 | 详情 |