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【结 构 式】 
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【药物名称】M-6434 【化学名称】2-[(5-Chloro-2-methoxyphenyl)azo]-1H-imidazole 【CA登记号】77636-92-1, 77636-84-1 (monoHCl) 【 分 子 式 】C10H9ClN4O 【 分 子 量 】236.66243 |
【开发单位】Mochida (Originator) 【药理作用】Cardiovascular Diseases (Not Specified), CARDIOVASCULAR DRUGS |
合成路线1
The diazotation of 2-amino-4-chloroanisole (I) with NaNO2 and HCl in water gives the corresponding diazonium salt (II), which is then condensed with imidazole (III) by means of NaOH and sodium acetate in water.
| 【1】 Niimura, I.; Maeda, S.; Okazaki, H. (Mochida Pharmaceutical Co., Ltd.); Azo cpds.. DE 3028928 . |
| 【2】 Mochida, E.; Suzuki, Y.; Onishi, H.; Kosuzume, H. (Mochida Pharmaceutical Co., Ltd.); Compsns. containing azo cpds. and use thereof for therapeutic treatment. GB 2057874 . |
| 【3】 Blancafort, P.; Serradell, M.N.; Grau, M.; Castaner, J.; M-6434. Drugs Fut 1982, 7, 12, 887. |
Extended Information