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【结 构 式】 
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【分子编号】36169 【品名】N-phenylbenzohydrazide 【CA登记号】 |
【 分 子 式 】C13H12N2O 【 分 子 量 】212.25116 【元素组成】C 73.57% H 5.7% N 13.2% O 7.54% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(III)The phenylhydrazone of benzaldehyde (I) is obtained in the usual way, phenylhydrazine (A) with benzaldehyde (B), which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III). Finally, this compound is condensed with levulinic acid (IV) at high temperature.
| 【1】 Francia, E.; Marin, A. (Uriach & Cia S.A.); Procedimiento de obtencion del acido 1-benzoil-2-metilindol-3-acetico. ES 471436 . |
| 【2】 Francia, E.; Garcia Rafanell, J.; Delmetacin. Drugs Fut 1983, 8, 9, 764. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (A) | 11818 | Phenyl hydrazine; 1-Phenylhydrazine | 100-63-0 | C6H8N2 | 详情 | 详情 |
| (I) | 36167 | benzaldehyde N-phenylhydrazone | 588-64-7 | C13H12N2 | 详情 | 详情 |
| (II) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (III) | 36169 | N-phenylbenzohydrazide | C13H12N2O | 详情 | 详情 | |
| (IV) | 36170 | 4-oxopentanoic acid | 123-76-2 | C5H8O3 | 详情 | 详情 |
| (C) | 36168 | N-phenyl-N'-[(E)-benzylidene]benzohydrazide | C20H16N2O | 详情 | 详情 |
Extended Information