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【结 构 式】 
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【药物名称】Demetacin, Delmetacin, UR-2310 【化学名称】1-Benzoyl-2-methylindole-3-acetic acid 【CA登记号】16401-80-2 【 分 子 式 】C18H15NO3 【 分 子 量 】293.32515 |
【开发单位】Uriach (Originator) 【药理作用】Non-Steroidal Antiinflammatory Drugs |
合成路线1
The phenylhydrazone of benzaldehyde (I) is obtained in the usual way, phenylhydrazine (A) with benzaldehyde (B), which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III). Finally, this compound is condensed with levulinic acid (IV) at high temperature.
| 【1】 Francia, E.; Marin, A. (Uriach & Cia S.A.); Procedimiento de obtencion del acido 1-benzoil-2-metilindol-3-acetico. ES 471436 . |
| 【2】 Francia, E.; Garcia Rafanell, J.; Delmetacin. Drugs Fut 1983, 8, 9, 764. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (B) | 10498 | Benzaldehyde;Benzoic aldehyde;Phenylmethanal | 100-52-7 | C7H6O | 详情 | 详情 |
| (A) | 11818 | Phenyl hydrazine; 1-Phenylhydrazine | 100-63-0 | C6H8N2 | 详情 | 详情 |
| (I) | 36167 | benzaldehyde N-phenylhydrazone | 588-64-7 | C13H12N2 | 详情 | 详情 |
| (II) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (III) | 36169 | N-phenylbenzohydrazide | C13H12N2O | 详情 | 详情 | |
| (IV) | 36170 | 4-oxopentanoic acid | 123-76-2 | C5H8O3 | 详情 | 详情 |
| (C) | 36168 | N-phenyl-N'-[(E)-benzylidene]benzohydrazide | C20H16N2O | 详情 | 详情 |
Extended Information