N-phenyl-N'-[(E)-benzylidene]benzohydrazide -Drug Synthesis Database

【结构式】

【分子编号】36168

【品名】N-phenyl-N'-[(E)-benzylidene]benzohydrazide

【CA登记号】

【分子式】C₂₀H₁₆N₂O

【分子量】300.35992

【元素组成】C 79.98% H 5.37% N 9.33% O 5.33%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号：(C)

The phenylhydrazone of benzaldehyde (I) is obtained in the usual way, phenylhydrazine (A) with benzaldehyde (B), which by reaction with benzoyl chloride (II) gives (C) and further treatment with HCl in an organic solvent results in the substituted hydrazine hydrochloride (III). Finally, this compound is condensed with levulinic acid (IV) at high temperature.

参考文献中间体

合成目标

【1】 Francia, E.; Marin, A. (Uriach & Cia S.A.); Procedimiento de obtencion del acido 1-benzoil-2-metilindol-3-acetico. ES 471436 .
【2】 Francia, E.; Garcia Rafanell, J.; Delmetacin. Drugs Fut 1983, 8, 9, 764.

中间体序号	中间体编号	品名	CAS号	分子式	供应商	用于合成
(B)	10498	Benzaldehyde;Benzoic aldehyde;Phenylmethanal	100-52-7	C₇H₆O	详情	详情
(A)	11818	Phenyl hydrazine; 1-Phenylhydrazine	100-63-0	C₆H₈N₂	详情	详情
(I)	36167	benzaldehyde N-phenylhydrazone	588-64-7	C₁₃H₁₂N₂	详情	详情
(II)	10463	Benzoyl chloride	98-88-4	C₇H₅ClO	详情	详情
(III)	36169	N-phenylbenzohydrazide		C₁₃H₁₂N₂O	详情	详情
(IV)	36170	4-oxopentanoic acid	123-76-2	C₅H₈O₃	详情	详情
(C)	36168	N-phenyl-N'-[(E)-benzylidene]benzohydrazide		C₂₀H₁₆N₂O	详情	详情

Extended Information