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【结 构 式】 
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【分子编号】35751 【品名】2-(benzoylamino)-2-[4-(diethoxyphosphoryl)phenyl]acetic acid 【CA登记号】 |
【 分 子 式 】C19H22NO6P 【 分 子 量 】391.360582 【元素组成】C 58.31% H 5.67% N 3.58% O 24.53% P 7.91% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(IV)Condensation of alpha-hydroxyhippuric acid (II) with bromobenzene (I) in methanesulfonic acid afforded the phenylglycine derivative (III). Further incorporation of the phosphonic acid was effected by palladium-catalyzed displacement of the bromide by diethyl phosphite to give (IV). Finally, acid hydrolysis of the benzamide and phosphite ester groups furnished the title compound.
| 【1】 Bigge, C.F.; et al.; Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. J Med Chem 1989, 32, 7, 1580-90. |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (I) | 13365 | Monobromobenzene; 1-Bromobenzene；Phenylbromide;bromobenzene | 108-86-1 | C6H5Br | 详情 | 详情 |
| (II) | 20606 | 2-(benzoylamino)-2-hydroxyacetic acid | 16555-77-4 | C9H9NO4 | 详情 | 详情 |
| (III) | 35750 | 2-(benzoylamino)-2-(4-bromophenyl)acetic acid | C15H12BrNO3 | 详情 | 详情 | |
| (IV) | 35751 | 2-(benzoylamino)-2-[4-(diethoxyphosphoryl)phenyl]acetic acid | C19H22NO6P | 详情 | 详情 |
Extended Information