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【结 构 式】

【分子编号】35750

【品名】2-(benzoylamino)-2-(4-bromophenyl)acetic acid

【CA登记号】

【 分 子 式 】C15H12BrNO3

【 分 子 量 】334.16922

【元素组成】C 53.91% H 3.62% Br 23.91% N 4.19% O 14.36%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(III)

Condensation of alpha-hydroxyhippuric acid (II) with bromobenzene (I) in methanesulfonic acid afforded the phenylglycine derivative (III). Further incorporation of the phosphonic acid was effected by palladium-catalyzed displacement of the bromide by diethyl phosphite to give (IV). Finally, acid hydrolysis of the benzamide and phosphite ester groups furnished the title compound.

1 Bigge, C.F.; et al.; Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. J Med Chem 1989, 32, 7, 1580-90.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13365 Monobromobenzene; 1-Bromobenzene;Phenylbromide;bromobenzene 108-86-1 C6H5Br 详情 详情
(II) 20606 2-(benzoylamino)-2-hydroxyacetic acid 16555-77-4 C9H9NO4 详情 详情
(III) 35750 2-(benzoylamino)-2-(4-bromophenyl)acetic acid C15H12BrNO3 详情 详情
(IV) 35751 2-(benzoylamino)-2-[4-(diethoxyphosphoryl)phenyl]acetic acid C19H22NO6P 详情 详情
Extended Information