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【结 构 式】

【药物名称】(?-PPG

【化学名称】(±)-2-Amino-2-(4-phosphonophenyl)acetic acid

【CA登记号】120667-15-4, 120667-18-7 (hydrochloride)

【 分 子 式 】C8H10NO5P

【 分 子 量 】231.1464

【开发单位】Merck & Co. (Originator), Novartis (Originator)

【药理作用】Antiepileptic Drugs, Cerebrovascular Diseases, Treatment of, NEUROLOGIC DRUGS, Stroke, Treatment of, mglu8 Agonists

合成路线1

Condensation of alpha-hydroxyhippuric acid (II) with bromobenzene (I) in methanesulfonic acid afforded the phenylglycine derivative (III). Further incorporation of the phosphonic acid was effected by palladium-catalyzed displacement of the bromide by diethyl phosphite to give (IV). Finally, acid hydrolysis of the benzamide and phosphite ester groups furnished the title compound.

1 Bigge, C.F.; et al.; Exploration of phenyl-spaced 2-amino-(5-9)-phosphonoalkanoic acids as competitive N-methyl-D-aspartic acid antagonists. J Med Chem 1989, 32, 7, 1580-90.
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(I) 13365 Monobromobenzene; 1-Bromobenzene;Phenylbromide;bromobenzene 108-86-1 C6H5Br 详情 详情
(II) 20606 2-(benzoylamino)-2-hydroxyacetic acid 16555-77-4 C9H9NO4 详情 详情
(III) 35750 2-(benzoylamino)-2-(4-bromophenyl)acetic acid C15H12BrNO3 详情 详情
(IV) 35751 2-(benzoylamino)-2-[4-(diethoxyphosphoryl)phenyl]acetic acid C19H22NO6P 详情 详情
Extended Information