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【结 构 式】

【分子编号】33855

【品名】N-(2-benzoyl-4-chlorophenyl)benzamide

【CA登记号】

【 分 子 式 】C20H14ClNO2

【 分 子 量 】335.7894

【元素组成】C 71.54% H 4.2% Cl 10.56% N 4.17% O 9.53%

与该中间体有关的原料药合成路线共 1 条

合成路线1

该中间体在本合成路线中的序号:(XIV)

The starting benzophenone (I) can also be obtained in several different ways: a) By a Friedel-Crafts reaction of p-chloroaniline (X) and benzoyl chloride (D). b) By reaction of 5-chloroanthranilic acid (XI) with acetic anhydride to the bicyclic compound (XII), which is then submitted to a Grignard reaction with phenylmagnesium bromide (E). c) By oxidation of 2,3-diphenyl-5-chloroindole (XIII) with CrO3 to the N-benzoylbenzophenone (XIV), followed by debenzoylation with NaOH.

1 Topliss, J.G.; 1-Polyhalogenoalkyl-2-oxo-1,3-dihydro-2H-14-benzodiazepines. US 3429874 .
2 Topliss, J.G.; 2-Polyfluoroweralkyl benzophenones. US 3641147 .
中间体序号 中间体编号 品名 CAS号 分子式 供应商 用于合成
(D) 10463 Benzoyl chloride 98-88-4 C7H5ClO 详情 详情
(E) 17616 bromo(phenyl)magnesium; Phenyl Magnesium Bromide 100-58-3 C6H5BrMg 详情 详情
(I) 10279 (2-Amino-5-chlorophenyl)(phenyl)methanone; 2-Amino-5-chlorobenzophenone 719-59-5 C13H10ClNO 详情 详情
(X) 12034 4-Chlorophenylamine; 4-Chloroaniline; p-Chloroaniline 106-47-8 C6H6ClN 详情 详情
(XI) 10285 2-Amino-5-chlorobenzoic acid 635-21-2 C7H6ClNO2 详情 详情
(XII) 33853 6-chloro-2-methyl-4H-3,1-benzoxazin-4-one C9H6ClNO2 详情 详情
(XIII) 33854 5-chloro-2,3-diphenyl-1H-indole C20H14ClN 详情 详情
(XIV) 33855 N-(2-benzoyl-4-chlorophenyl)benzamide C20H14ClNO2 详情 详情
Extended Information