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【结 构 式】 
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【分子编号】33854 【品名】5-chloro-2,3-diphenyl-1H-indole 【CA登记号】 |
【 分 子 式 】C20H14ClN 【 分 子 量 】303.7906 【元素组成】C 79.07% H 4.65% Cl 11.67% N 4.61% |
与该中间体有关的原料药合成路线共 1 条
合成路线1
该中间体在本合成路线中的序号：(XIII)The starting benzophenone (I) can also be obtained in several different ways: a) By a Friedel-Crafts reaction of p-chloroaniline (X) and benzoyl chloride (D). b) By reaction of 5-chloroanthranilic acid (XI) with acetic anhydride to the bicyclic compound (XII), which is then submitted to a Grignard reaction with phenylmagnesium bromide (E). c) By oxidation of 2,3-diphenyl-5-chloroindole (XIII) with CrO3 to the N-benzoylbenzophenone (XIV), followed by debenzoylation with NaOH.
| 【1】 Topliss, J.G.; 1-Polyhalogenoalkyl-2-oxo-1,3-dihydro-2H-14-benzodiazepines. US 3429874 . |
| 【2】 Topliss, J.G.; 2-Polyfluoroweralkyl benzophenones. US 3641147 . |
| 中间体序号 | 中间体编号 | 品名 | CAS号 | 分子式 | 供应商 | 用于合成 |
|---|---|---|---|---|---|---|
| (D) | 10463 | Benzoyl chloride | 98-88-4 | C7H5ClO | 详情 | 详情 |
| (E) | 17616 | bromo(phenyl)magnesium; Phenyl Magnesium Bromide | 100-58-3 | C6H5BrMg | 详情 | 详情 |
| (I) | 10279 | (2-Amino-5-chlorophenyl)(phenyl)methanone; 2-Amino-5-chlorobenzophenone | 719-59-5 | C13H10ClNO | 详情 | 详情 |
| (X) | 12034 | 4-Chlorophenylamine; 4-Chloroaniline; p-Chloroaniline | 106-47-8 | C6H6ClN | 详情 | 详情 |
| (XI) | 10285 | 2-Amino-5-chlorobenzoic acid | 635-21-2 | C7H6ClNO2 | 详情 | 详情 |
| (XII) | 33853 | 6-chloro-2-methyl-4H-3,1-benzoxazin-4-one | C9H6ClNO2 | 详情 | 详情 | |
| (XIII) | 33854 | 5-chloro-2,3-diphenyl-1H-indole | C20H14ClN | 详情 | 详情 | |
| (XIV) | 33855 | N-(2-benzoyl-4-chlorophenyl)benzamide | C20H14ClNO2 | 详情 | 详情 |
Extended Information